Evidence map›Paper›PMID 32457078›Full record

ArticleBMJ open2020

Efficacy of maternal B

Jitender Nagpal, Manu Raj Mathur, Swapnil Rawat, Deepti Nagrath, Charlotte Lee, Atul Singhal, Michelle Heys, Mario Cortina Borja, Katrin Augustin, Jageshwor Gautam and 3 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Maternal supplementation of vitamin BBMJ paediatrics open · 2026
    Trial
  3. Article
  4. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

Jitender NagpalPediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, Delhi, India.
Manu Raj MathurPublic Health Foundation of India, New Delhi, India.
Swapnil RawatPediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, Delhi, India.
Deepti NagrathPublic Health Foundation of India, New Delhi, India.ORCID 0000-0003-3854-1841
Charlotte LeeUCL GOS Institute of Child Health, University College London, London, UK.ORCID 0000-0001-8252-9538
Atul SinghalUCL GOS Institute of Child Health, University College London, London, UK.
Michelle HeysUCL GOS Institute of Child Health, University College London, London, UK.
Mario Cortina BorjaUCL GOS Institute of Child Health, University College London, London, UK.
Katrin AugustinUCL GOS Institute of Child Health, University College London, London, UK.
Jageshwor GautamObstetrics and Gynaecology, Paropakar Maternity & Women's Hospital, Kathmandu, Nepal.
Rajendra PantObstetrics and Gynaecology, Paropakar Maternity & Women's Hospital, Kathmandu, Nepal.
Laura SwabeyUCL GOS Institute of Child Health, University College London, London, UK.ORCID 0000-0001-6677-1420
Monica LakhanpaulUCL GOS Institute of Child Health, University College London, London, UK m.lakhanpaul@ucl.ac.uk.ORCID 0000-0001-5288-3325
Institute of Child Health · INPublic Health Foundation of India · INSitaram Bhartia Institute of Science and Research · INWomen's Hospital · USEast London NHS Foundation Trust · GBWhittington Health NHS Trust · GB

Funding

Medical Research Council MR/R020396/1
6 · The paper itself

Abstract

introductionVitamin B METHODS AND ANALYSIS: This double-blind, multicentre, randomised controlled trial will enrol 720 vegetarian pregnant women in their first trimester from antenatal clinics at two hospitals (one in India and one in Nepal). Eligible mothers who give written consent will be randomised to receive either 250 mcg methylcobalamin or 50 mcg (quasi control), from enrolment to 6 months post-partum, given as an oral daily capsule. All mothers and their infants will continue to receive standard clinical care. The primary trial outcome is the offspring's neurodevelopment status at 9 months of age, assessed using the Development Assessment Scale of Indian Infants. Secondary outcomes include the infant's biochemical B ETHICAL CONSIDERATIONS AND DISSEMINATION: The study protocol has been approved by ethical committees at each study site (India and Nepal) and at University College London, UK. The study results will be disseminated to healthcare professionals and academics globally via conferences, presentations and publications. Researchers at each study site will share results with participants during their follow-up visits.

Indexed as

Dietary SupplementsVegetariansAdultAvitaminosisCognitionDouble-Blind MethodFemaleHumansIndiaInfantInfant, NewbornMicronutrientsMothersMulticenter Studies as TopicNepalPregnancyMicronutrientsVitamin B 12community child healthdevelopmental neurology & neurodisabilitymaternal medicinenutrition & dieteticspaediatrics

Identifiers

PMID32457078
PMCPMC7252986
OpenAlexW3031150969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.