Evidence map›Paper›PMID 32457076›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

A Role of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytic Aβ Clearance.

Hongsheng Zhang, Wenbing Chen, Zhibing Tan, Lei Zhang, Zhaoqi Dong, Wanpeng Cui, Kai Zhao, Hongsheng Wang, Hongyang Jing, Rangjuan Cao and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. Canonical Pathways Rewiring in Alzheimer's Disease.International journal of molecular sciences · 2026
    Article
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  14. LRP10 and α-synuclein transmission in Lewy body diseases.Cellular and molecular life sciences : CMLS · 2024
    Article
  15. Review
  16. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Hongsheng ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.ORCID 0000-0001-8138-2108
Wenbing ChenDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Zhibing TanDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Lei ZhangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Zhaoqi DongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Wanpeng CuiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Kai ZhaoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Hongsheng WangDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Hongyang JingDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.ORCID 0000-0003-2811-1266
Rangjuan CaoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Chae KimDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Jiri G SafarDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106.
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 lin.mei@case.edu.ORCID 0000-0001-5772-1229
Case Western Reserve University · USLouis Stokes Cleveland VA Medical Center · US

Funding

Mechanisms of neuromuscular junction formationR01NS082007 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG · 2013 to 2022
$5.2M
Structural determinants of amyloid strain heterogeneity in distinct phenotypes of Alzheimer's diseaseRF1AG061797 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI JARONIEC, CHRISTOPHER P, SAFAR, JIRI G. · 2018 to 2021
$4.4M
NRG1-ErbB4 regulation of synaptic plasticity and behaviorR01MH083317 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2008 to 2018
$4.3M
Characterization of Rapidly Progressive Alzheimer's DiseaseRF1AG058267 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HAINES, JONATHAN L, SAFAR, JIRI G. · 2017 to 2017
$4.0M
Characterization of Agrin/LRP4 Antibody-Positive Myasthenia GravisR01NS090083 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MEI, LIN · 2015 to 2019
$2.9M
LRP4 deficiency in Alzheimer's disease developmentRF1AG066526 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.8M
Swedish APP mutation and NMJ decline in Alzheimer's diseaseRF1AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2020 to 2020
$2.6M
Swedish APP mutation and NMJ decline in Alzheimer's diseaseR01AG051510 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI XIONG, WEN-CHENG, ZIGMOND, RICHARD E · 2015 to 2024
$2.6M
NIA NIH HHS R01 AG051510NIA NIH HHS RF1 AG051510NIA NIH HHS RF1 AG058267NIA NIH HHS RF1 AG061797NIA NIH HHS RF1 AG066526NIMH NIH HHS R01 MH083317NINDS NIH HHS R01 NS082007NINDS NIH HHS R01 NS090083
6 · The paper itself

Abstract

Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is considered a cause of Alzheimer's disease (AD). The imbalance of Aβ production and clearance leads to Aβ accumulation and Aβ deposition. Increasing evidence indicates an important role of astrocytes, the most abundant cell type among glial cells in the brain, in Aβ clearance. We explored the role of low-density lipoprotein receptor-related protein 4 (LRP4), a member of the LDLR family, in AD pathology. We show that

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAstrocytesBrainDisease Models, AnimalFemaleHumansLDL-Receptor Related ProteinsMaleMicePlaque, AmyloidAmyloid beta-PeptidesLDL-Receptor Related ProteinsLRP4 protein, humanAlzheimer's diseaseamyloid-βastrocyteLRP4

Identifiers

PMID32457076
PMCPMC7343327
OpenAlexW3028888328

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.