ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Cholinergic Modulation of Binocular Vision.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Perceiving the uncertain: predictive coding and individual differences in the dynamics of multistable perception.Cognitive processing · 2026Review
- Adaptive arousal regulation: Pharmacologically shifting the peak of the Yerkes-Dodson curve by catecholaminergic enhancement of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Postural instability and gait disturbance are associated with abnormal stereopsis in Parkinson's disease.PloS one · 2025Article
- The complexity of human subjective experience during binocular rivalry.Neuroscience of consciousness · 2025Article
- Bistable perception, precision and neuromodulation.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021Review
- Characterization of Individual Projections Reveal That Neuromasts of the Zebrafish Lateral Line are Innervated by Multiple Inhibitory Efferent Cells.Frontiers in neuroanatomy · 2021Article
- Visual cortex cTBS increases mixed percept duration while a-tDCS has no effect on binocular rivalry.PloS one · 2021Article
- Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System.Frontiers in neural circuits · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The endogenous neurotransmitter acetylcholine (ACh) is known to affect the excitatory/inhibitory (E/I) balance of primate visual cortex, enhancing feedforward thalamocortical gain while suppressing corticocortical synapses. Recent advances in the study of the human visual system suggest that ACh is a likely component underlying interocular interactions. However, our understanding of its precise role in binocular processes is currently lacking. Here we use binocular rivalry as a probe of interocular dynamics to determine ACh's effects, via the acetylcholinesterase inhibitor (AChEI) donepezil, on the binocular visual system. A total of 23 subjects (13 male) completed two crossover experimental sessions where binocular rivalry measurements were obtained before and after taking either donepezil (5 mg) or a placebo (lactose) pill. We report that enhanced cholinergic potentiation attenuates perceptual suppression during binocular rivalry, reducing the overall rate of interocular competition while enhancing the visibility of superimposition mixed percepts. Considering recent evidence that perceptual suppression during binocular rivalry is causally modulated by the inhibitory neurotransmitter GABA, our results suggest that cholinergic activity counteracts the effect of GABA with regards to interocular dynamics and may modulate the inhibitory drive within the visual cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.