Evidence map›Paper›PMID 32457041›Full record

ArticleDisease models & mechanisms2020

A novel Cre-enabled tetracycline-inducible transgenic system for tissue-specific cytokine expression in the zebrafish: CETI-PIC3.

Sara Ibrahim, Arianna Harris-Kawano, Isra Haider, Raghavendra G Mirmira, Emily K Sims, Ryan M Anderson

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Immune-Enhancing Effects ofCurrent issues in molecular biology · 2026
    Article
  2. Inflammation in Development and Aging: Insights from the Zebrafish Model.International journal of molecular sciences · 2024
    Review
  3. Adult zebrafish as advanced models of human disease.Disease models & mechanisms · 2023
    Article
  4. An inducible model of chronic hyperglycemia.Disease models & mechanisms · 2023
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. What lies beyond 100 years of insulin.Disease models & mechanisms · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sara IbrahimDepartments of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Arianna Harris-KawanoCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Isra HaiderCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Raghavendra G MirmiraDepartments of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Emily K SimsCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA ryananderson@uchicago.edu eksims@iu.edu.ORCID 0000-0002-4393-954X
Ryan M AndersonCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA ryananderson@uchicago.edu eksims@iu.edu.ORCID 0000-0003-3413-0121
Indiana University School of MedicineUniversity of Chicago · US

Funding

Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI MANAMI HARA · 2013 to 2026
$20.9M
Transcriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Validation of small molecule 12-lipoxygenase inhibitors in metabolic diseaseR01DK105588 · NIDDK · UNIVERSITY OF CHICAGO · PI KULKARNI, ROHIT N., MIRMIRA, RAGHAVENDRA G · 2015 to 2024
$5.5M
Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and ReplicationR01DK124906 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2020 to 2026
$4.0M
Beta cell extracellular vesicles in health and diseaseR01DK121929 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI SIMS, EMILY K · 2020 to 2024
$2.0M
MiR-21 Exacerbates Cytokine Induced Beta Cell Dysfunction Via Inhibition of mRNAs Regulating Beta Cell IdentityF30DK122681 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI IBRAHIM, SARA · 2019 to 2021
$107k
NIDDK NIH HHS F30 DK122681NIDDK NIH HHS P30 DK020595NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK105588NIDDK NIH HHS R01 DK121929NIDDK NIH HHS R01 DK124906NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

Maladaptive signaling by pro-inflammatory cytokines (PICs), such as TNFα, IL1β and IFNɣ, can activate downstream signaling cascades that are implicated in the development and progression of multiple inflammatory diseases. Despite playing critical roles in pathogenesis, the availability of

Indexed as

AnimalsAnimals, Genetically ModifiedCytokinesEndoplasmic Reticulum StressGene Expression Regulation, DevelopmentalGlucoseInflammation MediatorsIntegrasesInterferon-gammaInterleukin-1betaOxidative StressTetracyclineTumor Necrosis Factor-alphaUp-RegulationZebrafishZebrafish ProteinsCre recombinaseCytokinesGlucoseInflammation MediatorsIntegrasesInterferon-gammaInterleukin-1betaTetracyclineTumor Necrosis Factor-alphaZebrafish ProteinsBeta cellCytokinesInflammationPancreasZebrafish

Identifiers

PMID32457041
PMCPMC7328138
OpenAlexW3032683323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.