SynthesisBMJ open gastroenterology2020
Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19.
Synthesis in BMJ open gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04854941 (Efficacy of Probiotics), which is not on this map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Probiotics (Lactobacillus Rhamnosus, Bifidobacterium Bifidum, Bifidobacterium Longum Subsp. Infantis and Bifidobacterium Longum) in the Treatment of Hospitalised Patients With Novel Coronavirus Infection
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Gastrointestinal Sequelae of COVID-19: Investigating Post-Infection Complications-A Systematic Review.Viruses · 2024Pooled it
- The importance of fecal nucleic acid detection in patients with coronavirus disease (COVID-19): A systematic review and meta-analysis.Journal of medical virology · 2022Pooled it
- Epidemiological and clinical characteristics of non-severe and severe pediatric and adult COVID-19 patients across different geographical regions in the early phase of pandemic: a systematic review and meta-analysis of observational studies.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021Pooled it
- The characteristics of gastrointestinal symptoms in patients with severe COVID-19: a systematic review and meta-analysis.Journal of gastroenterology · 2021Pooled it
- Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version).Military Medical Research · 2020Guideline
- COVID-19 gastrointestinal manifestations: a systematic review.Revista da Sociedade Brasileira de Medicina Tropical · 2020Pooled it
- Neurogenic Appendicopathy in Pediatric Appendectomies During the COVID-19 Era: A Retrospective Analysis of Histologically Negative Cases.International journal of pediatrics · 2026Article
- Genomic Characterization of SARS-CoV-2 NB.1.8.1 and PQ.2 from the Infants and Young Children with Gastrointestinal Symptoms.Infection and drug resistance · 2026Article
- Gastrointestinal Manifestations and Outcomes of COVID-19: A Comprehensive Systematic Review and Meta-analysis.Cureus · 2023Review
- Bleeding due to successive duodenal and rectal ulcers in an 81-year-old patient with severe COVID-19: a case report.BMC geriatrics · 2023Article
- Epidemiological features and consequences of COVID-19 in patients with and without gastrointestinal symptoms in southwestern Iran. A retrospective observational study.Health science reports · 2023Article
- Acute Appendicitis Following COVID-19 Infection in Pediatric Patients: A Single Center's Study in Greece.Diagnostics (Basel, Switzerland) · 2023Article
- Multi-effective characteristics and advantages of acupuncture in COVID-19 treatment.Acupuncture and herbal medicine · 2023Review
- The Outcome of COVID-19 Infection in Patients With Gastrointestinal Diseases: An Experience at a Tertiary Center.Cureus · 2023Article
- No sign of Rotavirus co-infection in COVID-19 patients with gastrointestinal symptoms.Malawi medical journal : the journal of Medical Association of Malawi · 2023Article
- Editorial: Inflammation and organic damage in COVID-19: what have we learned 2 years into the pandemic?Frontiers in medicine · 2023Article
- Acute Appendicitis in COVID-19-Positive Children: Report of 4 Cases from an Endemic Area in Northeastern Romania.International journal of environmental research and public health · 2022Article
- The pathogenesis of coronavirus-19 disease.Journal of biomedical science · 2022Review
- Gastrointestinal and sensory manifestations, nutrition management, and energy-protein intake in hospitalized patients with COVID-19.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2022Article
- Global research production pertaining to gastrointestinal involvement in COVID-19: A bibliometric and visualised study.World journal of gastrointestinal surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe COVID-19 epidemic has affected over 2.6 million people across 210 countries. Recent studies have shown that patients with COVID-19 experience relevant gastrointestinal (GI) symptoms. We aimed to perform a systematic review and meta-analysis on the GI symptoms of COVID-19.
methodsA literature search was conducted via electronic databases, including PubMed, Embase, Scopus, and Google Scholar, from inception until 20 March 2020. Data were extracted from relevant studies. A systematic review of GI symptoms and a meta-analysis comparing symptoms in severe and non-severe patients was performed using RevMan V.5.3.
resultsPooled data from 2477 patients with a reverse transcription-PCR-positive COVID-19 infection across 17 studies were analysed. Our study revealed that diarrhoea (7.8%) followed by nausea and/or vomiting (5.5 %) were the most common GI symptoms. We performed a meta-analysis comparing the odds of having GI symptoms in severe versus non-severe COVID-19-positive patients. 4 studies for nausea and/or vomiting, 5 studies for diarrhoea and 3 studies for abdominal pain were used for the analyses. There was no significant difference in the incidence of diarrhoea (OR=1.32, 95% CI 0.8 to 2.18, Z=1.07, p=0.28, I
conclusionOur study has reiterated that GI symptoms are an important clinical feature of COVID-19. Patients with severe disease are more likely to have abdominal pain as compared with patients with non-severe disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.