Evidence map›Paper›PMID 32456723›Full record

ArticleCardiology in the young2020

Quantitative cardiac magnetic resonance T2 imaging offers ability to non-invasively predict acute allograft rejection in children.

Neeta Sethi, Ashish Doshi, Tina Doshi, Russell Cross, Ileen Cronin, Elena Amin, Joshua Kanter, Janet Scheel, Sairah Khan, Adrienne Campbell-Washburn and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology in the young, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  8. Cardiac magnetic resonance assessment of acute rejection and cardiac allograft vasculopathy in pediatric heart transplant.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  9. Article
  10. Article
  11. Native T1 mapping detects both acute clinical rejection and graft dysfunction in pediatric heart transplant patients.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  12. Article
  13. T2 mapping in myocardial disease: a comprehensive review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Myocardial T1 and T2 values are associated with patient age in healthy pediatric heart transplant recipients.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Neeta SethiDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.ORCID https://orcid.org/0000-0003-4495-3578
Ashish DoshiDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Tina DoshiDivision of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD21205, USA.
Russell CrossDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Ileen CroninDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Elena AminDepartment of Pediatrics, University of California San Francisco, San Francisco, CA94143, USA.
Joshua KanterDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Janet ScheelDivision of Cardiology, St. Louis Children's Hospital, St. Louis, MO, 63110, USA.
Sairah KhanDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Adrienne Campbell-WashburnNational Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Laura OlivieriDivision of Cardiology, Children's National Hospital, Washington, DC20010, USA.
Children's National · USJohns Hopkins University · USNational Institutes of Health · USSt. Louis Children's Hospital · USUniversity of California, San Francisco · US

Funding

Cardiac MRI Increases Accuracy and Decreases Risk of Evaluation of Children with Cardiomyopathy and Cardiac TransplantationR01HL144494 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OLIVIERI, LAURA J · 2019 to 2023
$3.6M
NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS R01 HL144494
6 · The paper itself

Abstract

backgroundMonitoring for acute allograft rejection improves outcomes after cardiac transplantation. Endomyocardial biopsy is the gold standard test defining rejection, but carries risk and has limitations. Cardiac magnetic resonance T2 mapping may be able to predict rejection in adults, but has not been studied in children. Our aim was to evaluate T2 mapping in identifying paediatric cardiac transplant patients with acute rejection.

methodsEleven paediatric transplant patients presenting 18 times were prospectively enrolled for non-contrast cardiac magnetic resonance at 1.5 T followed by endomyocardial biopsy. Imaging included volumetry, flow, and T2 mapping. Regions of interest were manually selected on the T2 maps using the middle-third technique in the left ventricular septal and lateral wall in a short-axis and four-chamber slice. Mean and maximum T2 values were compared with Student's t-tests analysis.

resultsFive cases of acute rejection were identified in three patients, including two cases of grade 2R on biopsy and three cases of negative biopsy treated for clinical symptoms attributed to rejection (new arrhythmia, decreased exercise capacity). A monotonic trend between increasing T2 values and higher biopsy grades was observed: grade 0R T2 53.4 ± 3 ms, grade 1R T2 54.5 ms ± 3 ms, grade 2R T2 61.3 ± 1 ms. The five rejection cases had significantly higher mean T2 values compared to cases without rejection (58.3 ± 4 ms versus 53 ± 2 ms, p = 0.001).

conclusionsCardiac magnetic resonance with quantitative T2 mapping may offer a non-invasive method for screening paediatric cardiac transplant patients for acute allograft rejection. More data are needed to understand the relationship between T2 and rejection in children.

Indexed as

Magnetic Resonance Imaging, CineAcute DiseaseAdolescentChildChild, PreschoolFemaleGraft RejectionHeart TransplantationHumansLogistic ModelsMaleMyocardiumPredictive Value of TestsTransplantation, HomologousTreatment OutcomeUnited Statesallograft rejectioncardiac magnetic resonanceheart transplantPaediatricT2 mapping

Identifiers

PMID32456723
PMCPMC7654096
OpenAlexW3031585587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.