Evidence map›Paper›PMID 32456678›Full record

ArticleBMC pediatrics2020

Normative values for circulating intestinal fatty acid binding protein and calprotectin across gestational ages.

Darla R Shores, Jennifer Fundora, Mitzi Go, Fauzia Shakeel, Sandra Brooks, Samuel M Alaish, Jun Yang, Chhinder P Sodhi, David J Hackam, Allen Everett

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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  13. [Clinical guidelines for the diagnosis and treatment of neonatal necrotizing enterocolitis (2020)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Darla R ShoresDepartment of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Johns Hopkins School of Medicine, 600 N. Wolfe St, CMSC 2-116, Baltimore, MD, 21187, USA. dshores1@jhmi.edu.ORCID 0000-0002-0551-7880
Jennifer FundoraDepartment of Pediatrics, Johns Hopkins Hospital, 1800 Orleans St, Ste 8520, Baltimore, MD, 21287, USA.
Mitzi GoDepartment of Pediatrics, Division of Neonatology, Johns Hopkins Medicine All Children's Hospital, 600 5th Street South, St. Petersburg, FL, 33701, USA.
Fauzia ShakeelDepartment of Pediatrics, Division of Maternal Fetal and Neonatal Institute Johns Hopkins All Children's Hospital, 601 5th Street South, St. Petersburg, FL, 33701, USA.
Sandra BrooksDepartment of Pediatrics, Division of Neonatology, Johns Hopkins Medicine All Children's Hospital, 600 5th Street South, St. Petersburg, FL, 33701, USA.
Samuel M AlaishDepartment of Surgery, Division of General Pediatric Surgery, Johns Hopkins School of Medicine, 1800 Orleans Street, Room 7337, Baltimore, MD, 21287, USA.
Jun YangDepartment of Pediatrics, Division of Cardiology, Johns Hopkins School of Medicine, 720 Rutland Ave, Ross 1143, Baltimore, MD, 21205, USA.
Chhinder P SodhiDepartment of Surgery, Division of General Pediatric Surgery, Johns Hopkins School of Medicine, 1800 Orleans Street, Room 7337, Baltimore, MD, 21287, USA.
David J HackamDepartment of Surgery, Division of General Pediatric Surgery, Johns Hopkins School of Medicine, 1800 Orleans Street, Room 7337, Baltimore, MD, 21287, USA.
Allen EverettDepartment of Pediatrics, Division of Cardiology, Johns Hopkins School of Medicine, 720 Rutland Ave, Ross 1143, Baltimore, MD, 21205, USA.
Johns Hopkins University · USJohns Hopkins Hospital · US

Funding

Institutional Training for PediatriciansT32HD044355 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BRADY, TAMMY MCLOUGHLIN · 2003 to 2023
$4.1M
NICHD NIH HHS T32 HD044355
6 · The paper itself

Abstract

backgroundNecrotizing enterocolitis (NEC) is associated with significant morbidity and mortality. Serum biomarkers to aid diagnosis, such as intestinal fatty acid binding protein (IFABP) and calprotectin, are actively being investigated; however, the normative values of these markers among healthy premature and term infants remains unknown. We sought to identify normative values for the serum concentrations of IFABP and calprotectin across gestational (GA) and post-menstrual age.

methodsWe collected serum from infants (24-40 weeks GA) in the first week of life and at multiple time points in a sub-cohort of premature infants (24-29 weeks GA), excluding sepsis or known intestinal disease. IFABP and calprotectin were measured using ELISA. Groups were compared with descriptive statistics and mixed effects linear regression.

resultsOne hundred twelve infants had specimens in the first week of life, and 19 premature infants had longitudinal specimens. IFABP concentration in the first week of life was low and did not differ across gestational ages. Longitudinally, IFABP increased 4% per day (P < 0.001). Calprotectin concentration in the first week of life was more variable. An inverse relationship between day of life and calprotectin level was found in the longitudinal cohort (P < 0.001).

conclusionsSerum IFABP and calprotectin fluctuate over time. Infants had low levels of IFABP during the first week of life, independent of gestational age, and levels increased longitudinally in premature infants. Calprotectin levels generally declined over time. Normative data for infants is necessary to establish meaningful cut-off levels for clinical use.

Indexed as

Enterocolitis, NecrotizingLeukocyte L1 Antigen ComplexBiomarkersFatty Acid-Binding ProteinsFecesGestational AgeHumansInfant, NewbornBiomarkersFatty Acid-Binding ProteinsLeukocyte L1 Antigen ComplexBiomarkerCalprotectinIntestinal fatty acid binding proteinNecrotizing enterocolitisNeonate

Identifiers

PMID32456678
PMCPMC7249444
OpenAlexW3031569179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.