Evidence map›Paper›PMID 32456669›Full record

ArticleBMC pediatrics2020

Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

Dara Petel, Michelle Barton, Christian Renaud, Lynda Ouchenir, Jason Brophy, Jennifer Bowes, Sarah Khan, Ari Bitnun, Jane McDonald, Andrée-Anne Boisvert and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Enteroviral Infections in the First Three Months of Life.Pathogens (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Dara PetelDepartment of Pediatrics, Western University, London, Ontario, Canada.
Michelle BartonDepartment of Pediatrics, Western University, London, Ontario, Canada.
Christian RenaudDepartment of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
Lynda OuchenirDepartment of Pediatrics, University of Montreal, Montreal, Quebec, Canada.
Jason BrophyDepartment of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada.
Jennifer BowesChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Sarah KhanDepartment of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Ari BitnunDepartment of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
Jane McDonaldDepartment of Pediatrics, McGill University, Montreal, Quebec, Canada.
Andrée-Anne BoisvertDepartment of Pediatrics, McGill University, Montreal, Quebec, Canada.
Joseph TingDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Ashley RobertsDepartment of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Joan L RobinsonDepartment of Pediatrics, University of Alberta, 4-590 ECHA, 11405-87 Ave, Edmonton, AB, T6G 1C9, Canada. jr3@ualberta.ca.ORCID 0000-0001-9831-5681
McGill University · CAUniversité de Montréal · CAUniversity of British Columbia · CAUniversity of Ottawa · CAWestern University · CAMcMaster University · CAUniversity of Alberta · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome.

methodsIn this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network on Infections in Canada identified infants < 90 days of age with CNS infection proven to be due to enterovirus (EV) or herpes simplex virus (HSV) January 1, 2013 through December 31, 2014.

resultsOf 174 CNS infections with a proven etiology, EV accounted for 103 (59%) and HSV for 7 (4%). All HSV cases and 41 (40%) EV cases presented before 21 days of age. Four HSV cases (57%) and 5 EV cases (5%) had seizures. Three (43%) HSV and 23 (23%) EV cases lacked cerebrospinal fluid (CSF) pleocytosis. HSV cases were more likely to require ICU admission (p = 0.010), present with seizures (p = 0.031) and have extra-CNS disease (p < 0.001). Unfavorable outcome occurred in 12 cases (11% of all EV and HSV infections) but was more likely following HSV than EV infection (4 (57%) versus 8 (8%); p = 0.002).

conclusionsViruses accounted for approximately two-thirds of proven CNS infections in the first 90 days of life. Empiric therapy for HSV should be considered in suspected CNS infections in the first 21 days even in the absence of CSF pleocytosis unless CSF parameters are suggestive of bacterial meningitis. Neurodevelopmental follow-up should be considered in infants whose course of illness is complicated by seizures.

Indexed as

Central Nervous System InfectionsCentral Nervous System Viral DiseasesHerpes SimplexCanadaCentral Nervous SystemChildCross-Sectional StudiesHumansInfantRetrospective StudiesSimplexvirusCentral nervous system infectionMeningitisMeningoencephalitisNeonate

Identifiers

PMID32456669
PMCPMC7249448
OpenAlexW3032022986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.