Evidence map›Paper›PMID 32456484›Full record

ReviewDrug metabolism reviews2020

Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).

Laura E Russell, Mary Alexandra Schleiff, Eric Gonzalez, Aaron G Bart, Fabio Broccatelli, Jessica H Hartman, W Griffith Humphreys, Volker M Lauschke, Iain Martin, Chukwunonso Nwabufo and 6 more

Open access · greenAbstract readReview
In one paragraph

Review in Drug metabolism reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Automated Annotation of Sites of Metabolism from Biotransformation Data.Journal of chemical information and modeling · 2025
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 4 countries.

Laura E RussellDepartment of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.ORCID 0000-0001-9636-4455
Mary Alexandra SchleiffDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0003-3594-6835
Eric GonzalezDivision of Pre-Clinical Innovation, Therapeutic Development Branch, National Center for Advancing Translational Sciences, Bethesda, MD, USA.
Aaron G BartProgram in Biophysics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8605-4151
Fabio BroccatelliDepartment of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.
Jessica H HartmanNicholas School of the Environment, Duke University, Durham, NC, USA.ORCID 0000-0002-9032-7191
W Griffith HumphreysAranmore Pharma Consulting, Lawrenceville, NJ, USA.
Volker M LauschkeDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Iain MartinRelay Therapeutics, Cambridge, MA, USA.
Chukwunonso NwabufoGilead Alberta ULC, Edmonton, AB, Canada.ORCID 0000-0002-1889-0334
Bhagwat PrasadCollege of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA.
Emily E ScottProgram in Biophysics, University of Michigan, Ann Arbor, MI, USA.
Matthew SegallOptibrium Limited, Cambridge, UK.
Ryan TakahashiDenali Therapeutics, South San Francisco, CA, USA.
Mitchell E TaubDepartment of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT, USA.
Jasleen K SodhiDepartment of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-6187-5597
University of Michigan · USBoehringer Ingelheim (United States) · USDenali Therapeutics (United States) · USDuke University · USGilead Sciences (Canada) · CAKarolinska Institutet · SENovartis (United States) · USOptibrium (United Kingdom) · GBRelay Therapeutics (United States) · USUniversity of Arkansas for Medical Sciences · USUniversity of California, San Francisco · USWashington State University Spokane · USWestern University · CA

Funding

Maximizing Opportunities for Research Excellence - Evaluation Training SupplementR25GM056847 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUNCAN, D'ANNE S., SELLO, JASON K · 1998 to 2023
$14.1M
TRAINING GRANT IN DYNAMIC ASPECTS OF CHEMICAL BIOLOGYT32GM008545 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LAMB, AUDREY L · 1994 to 2019
$4.9M
Structural Basis of Cytochrome P450 Activity-Equipment SupplementR37GM076343 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT, EMILY E · 2015 to 2024
$3.7M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
NIGMS NIH HHS R25 GM056847NIGMS NIH HHS R37 GM076343NIGMS NIH HHS T32 GM008545NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

The 12th International Society for the Study of Xenobiotics (ISSX) meeting, held in Portland, OR, USA from July 28 to 31, 2019, was attended by diverse members of the pharmaceutical sciences community. The ISSX New Investigators Group provides learning and professional growth opportunities for student and early career members of ISSX. To share meeting content with those who were unable to attend, the ISSX New Investigators herein elected to highlight the "

Indexed as

Computational BiologyDrug DiscoveryXenobioticsCongresses as TopicMachine LearningPharmaceutical PreparationsQuantum TheoryPharmaceutical PreparationsXenobioticsBiosynthetic lead diversificationCYP1A1cytochrome P450drug metabolismmatched molecular pairsmolecular dockingpredictive toolssite of metabolismX-ray crystallography

Identifiers

PMID32456484
PMCPMC7466845
OpenAlexW3029685194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.