ArticleMolecules (Basel, Switzerland)2020
Dilute-and-Shoot HPLC-UV Method for Determination of Urinary Creatinine as a Normalization Tool in Mycotoxin Biomonitoring in Pigs.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Machine Learning-Guided Cobalt@Copper Dual-Metal Electrochemical Sensor for Urinary Creatinine Detection.ACS sensors · 2025Article
- Improved solution-based SERS detection of creatinine by inducing hydrogen-bonding interaction for effective analyte capture.Talanta · 2024Article
- Article
- Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.International journal of molecular sciences · 2024Article
- MOF-Based Mycotoxin Nanosensors for Food Quality and Safety Assessment through Electrochemical and Optical Methods.Molecules (Basel, Switzerland) · 2022Review
- Development and Validation of LC-Q-TOF-MS Methodology to Determine Mycotoxin Biomarkers in Human Urine.Toxins · 2022Article
- Article
- Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods.Journal of animal science and biotechnology · 2021Review
- Review
- Development of a multi-mycotoxin LC-MS/MS method for the determination of biomarkers in pig urine.Mycotoxin research · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A simple, rapid, and accurate HPLC-UV method was developed for the determination of creatinine in pig urine. Usually, it is determined in urine in biomonitoring of xenobiotics to correct for variations in dilutions of urine samples. The colorimetric method (based on Jaffe reaction), which was mainly used for this purpose in mycotoxin biomonitoring, is not a reliable approach for pig urine. Therefore, a novel and accurate HPLC method for creatinine determination was developed. The sample preparation was based on the dilute and shoot approach. An HPLC separation was performed with a porous graphitic carbon column with an aqueous mobile phase to achieve satisfactory retention time for creatinine. The method has been successfully validated, applied for the determination of creatinine in pig urine, and compared with other methods commonly used for that purpose-a colorimetric method based on Jaffe reaction and commercial ELISA test. The developed HPLC method shows the highest precision and accuracy for pig urine samples. Finally, the method was applied as a normalization tool in LC-MS/MS mycotoxin biomarkers analysis. The standardization to a constant creatinine level (0.5 mg/mL) enables similar matrix effects for eleven mycotoxin biomarkers for pig urine samples with different creatinine levels.
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Registered trials
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