Evidence map›Paper›PMID 32456298›Full record

SynthesisInternational journal of molecular sciences2020

Sex Specific Determinants in Osteoarthritis: A Systematic Review of Preclinical Studies.

Deyanira Contartese, Matilde Tschon, Monica De Mattei, Milena Fini

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Journal of clinical medicine · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Deyanira ContarteseLaboratory of Preclinical and Surgical Studies, Rizzoli RIT Department, IRCCS-Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Matilde TschonLaboratory of Preclinical and Surgical Studies, Rizzoli RIT Department, IRCCS-Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Monica De MatteiDepartment of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Milena FiniLaboratory of Preclinical and Surgical Studies, Rizzoli RIT Department, IRCCS-Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Istituto Ortopedico Rizzoli · ITUniversity of Ferrara · IT

Funding

Network IRCCS AGING, Rete Nazionale di Ricerca sull'invecchiamento e la longevità attiva - Implementazione della RoadMap nella ricerca sull'Aging (IRMA) -
6 · The paper itself

Abstract

Osteoarthritis (OA) is a highly prevalent joint disease that primarily affects about 10% of the world's population over 60 years old. The purpose of this study is to systematically review the preclinical studies regarding sex differences in OA, with particular attention to the molecular aspect and gene expression, but also to the histopathological aspects. Three databases (PubMed, Scopus, and Web of Knowledge) were screened for eligible studies. In vitro and in vivo papers written in English, published in the last 11 years (2009-2020) were eligible. Participants were preclinical studies, including cell cultures and animal models of OA, evaluating sex differences. Independent extraction of articles and quality assessments were performed by two authors using predefined data fields and specific tools (Animals in Research Reporting In Vivo Experiments (ARRIVE) guideline and Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool). Twenty-three studies were included in the review: 4 in vitro studies, 18 in vivo studies, and 1 both in vitro and in vivo study. From in vitro works, sex differences were found in the gene expression of inflammatory molecules, hormonal receptors, and in responsiveness to hormonal stimulation. In vivo research showed a great heterogeneity of animal models mainly focused on the histopathological aspects rather than on the analysis of sex-related molecular mechanisms. This review highlights that many gaps in knowledge still exist; improvementsin the selection and reporting of animal models, the use of advanced in vitro models, and multiomics analyses might contribute to developing a personalized gender-based medicine.

Indexed as

AnimalsDisease Models, AnimalDogsFemaleGene Expression RegulationGuinea PigsHumansMaleMiceOsteoarthritisPapioRatsSex CharacteristicsSex FactorsSwinegendergender medicinemolecular mechanismsosteoarthritispreclinical modelsex

Identifiers

PMID32456298
PMCPMC7279293
OpenAlexW3027886998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.