Evidence map›Paper›PMID 32456225›Full record

ArticleInternational journal of molecular sciences2020

Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction.

Adelina Curaj, David Schumacher, Mihaela Rusu, Mareike Staudt, Xiaofeng Li, Sakine Simsekyilmaz, Vera Jankowski, Joachim Jankowski, Andreea Ramona Dumitraşcu, Derek J Hausenloy and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 6 countries.

Adelina CurajInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
David SchumacherInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-2308-6543
Mihaela RusuInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Mareike StaudtInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Xiaofeng LiInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Sakine SimsekyilmazInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Vera JankowskiInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Joachim JankowskiInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.
Andreea Ramona DumitraşcuInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0001-5593-3623
Derek J HausenloyCardiovascular & Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore 169857, Singapore.ORCID 0000-0003-0729-4956
Alexander SchuhDepartment of Cardiology, Pulmonology, Angiology and Intensive Care, University Hospital, RWTH Aachen University, 52074 Aachen, Germany.
Elisa A LiehnInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.ORCID 0000-0002-1253-3272
RWTH Aachen University · DEUniversity of Medicine and Pharmacy of Craiova · ROAsia University · TWDüsseldorf University Hospital · DEInstitutul National Victor Babes · ROMaastricht University · NL

Funding

British Heart Foundation FS/10/039/28270Deutsche Forschungsgemeinschaft DFG SFB/TRR219Interdisciplinary Centre for Clinical Research IZKF Aachen junior research group to E.A.L.
6 · The paper itself

Abstract

aimRecruitment of neutrophils to the heart following acute myocardial infarction (MI) initiates inflammation and contributes to adverse post-infarct left ventricular (LV) remodeling. However, therapeutic inhibition of neutrophil recruitment into the infarct zone has not been beneficial in MI patients, suggesting a possible dual role for neutrophils in inflammation and repair following MI. Here, we investigate the effect of neutrophils on cardiac fibroblast function following MI.

Indexed as

Wound HealingAnimalsCell CommunicationCells, CulturedCoculture TechniquesCollagenExtracellular MatrixMaleMiceMice, Inbred C57BLMyocardial InfarctionMyofibroblastsNeutrophilsTransforming Growth Factor betaCollagenTransforming Growth Factor betaextracellular matrix formationfibroblastsinflammationmyocardial infarctionneutrophilsscar formation

Identifiers

PMID32456225
PMCPMC7279328
OpenAlexW3027282555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.