ArticleJournal of clinical medicine2020
Role of Menopausal Transition and Physical Activity in Loss of Lean and Muscle Mass: A Follow-Up Study in Middle-Aged Finnish Women.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- Comparative effectiveness and dose-response relationship of exercise-based interventions for muscle mass in older women with sarcopenia: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Pooled it
- Effects of resistance training on muscle mass, strength, and physical function in older women with sarcopenia: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Effects of transdermal estrogen therapy on satellite cell number and molecular markers for muscle hypertrophy in response to resistance training in early postmenopausal women.European journal of applied physiology · 2023Trial
- Article
- Article
- Obstetric and urogynecological history are associated with lower limb strength and physical performance in middle-age and older women: a community-based cross-sectional study.BMC women's health · 2026Observational
- Associations between body composition and bone loss in early postmenopausal women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Menopause, Female Sex Hormones, Skeletal Muscle Mass and Muscle Protein Turnover in Humans.Journal of cachexia, sarcopenia and muscle · 2026Review
- Associations between the serum follicle-stimulating hormone (FSH) levels and intervertebral disc degeneration severity during the menopausal transition.Journal of orthopaedic surgery and research · 2026Article
- The Impact of the Menopausal Transition on Body Composition and Abdominal Fat Redistribution.Journal of clinical medicine · 2026Article
- Supporting the health of working women in midlife: co-designing and testing the acceptability of a digital exercise programme.BMC women's health · 2026Article
- Sarcopenia risk in women with postmenopausal osteoporosis: a SARC-F-based assessment.Turkish journal of medical sciences · 2026Article
- Hysterectomy accelerates sarcopenia risk in US women and mouse models.Frontiers in endocrinology · 2026Article
- The contribution of age and sex hormones to female neuromuscular function across the adult lifespan.The Journal of physiology · 2026Article
- Risk of Sarcopenic Obesity Across Menopausal Transition Stages in Middle-Aged Korean Women.Nutrients · 2025Article
- Middle-aged Korean women's experiences of physical activity during the transition to menopause: a grounded theory approach.Women's health nursing (Seoul, Korea) · 2025Article
- Vitamin D sufficiency and its relationship with muscle health across the menopausal transition and aging: Finnish cohorts of middle-aged women and older women and men.European journal of clinical nutrition · 2025Article
- Aerobic capacity and cardiopulmonary variables are not different between premenopausal, late premenopausal, perimenopausal, and postmenopausal women.Physiological reports · 2025Article
- Associations of Habitual Skeletal Loading with Bone Changes during the Menopausal Transition: A Follow-Up Study.Medicine and science in sports and exercise · 2025Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
In midlife, women experience hormonal changes due to menopausal transition. A decrease especially in estradiol has been hypothesized to cause loss of muscle mass. This study investigated the effect of menopausal transition on changes in lean and muscle mass, from the total body to the muscle fiber level, among 47-55-year-old women. Data were used from the Estrogenic Regulation of Muscle Apoptosis (ERMA) study, where 234 women were followed from perimenopause to early postmenopause. Hormone levels (estradiol and follicle stimulating hormone), total and regional body composition (dual-energy X-ray absorptiometry (DXA) and computed tomography (CT) scans), physical activity level (self-reported and accelerometer-measured) and muscle fiber properties (muscle biopsy) were assessed at baseline and at early postmenopause. Significant decreases were seen in lean body mass (LBM), lean body mass index (LBMI), appendicular lean mass (ALM), appendicular lean mass index (ALMI), leg lean mass and thigh muscle cross-sectional area (CSA). Menopausal status was a significant predictor for all tested muscle mass variables, while physical activity was an additional significant contributor for LBM, ALM, ALMI, leg lean mass and relative muscle CSA. Menopausal transition was associated with loss of muscle mass at multiple anatomical levels, while physical activity was beneficial for the maintenance of skeletal muscle mass.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.