ReviewInternational journal of environmental research and public health2020
Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation.
Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Trial
- Altered Sensory Processing in Restless Legs Syndrome: Associations With Disease Severity.Brain and behavior · 2026Article
- Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.Food science & nutrition · 2025Article
- Restless legs syndrome and its association with lower extremity adipose tissue thickness: a novel perspective.Arquivos de neuro-psiquiatria · 2025Article
- Association of restless legs syndrome and obesity: A sub-population of the MASHAD cohort study.Neurobiology of sleep and circadian rhythms · 2025Article
- Reported daytime sleepiness in relation to orthopnea, restless legs and nocturia in patients evaluated for suspected obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Prevalence of restless leg syndrome and associated comorbidities in a sub-saharan African general population: results from the Benin Society and Sleep (BeSAS) study.Sleep & breathing = Schlaf & Atmung · 2025Article
- Article
- Experiences of facilitators and barriers for fulfilment of human needs when living with restless legs syndrome: a qualitative study.International journal of qualitative studies on health and well-being · 2024Article
- Article
- Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis-Ekbom Disease.Life (Basel, Switzerland) · 2024Article
- Perceptions of exercise and restless legs syndrome: Results from a nationwide survey.Journal of sleep research · 2024Article
- Proteomic insights into the pathophysiology of periodic limb movements and restless legs syndrome.Sleep health · 2024Article
- Case report: A new treatment for restless leg syndrome: three cases.Frontiers in neuroscience · 2024Article
- Vitamin D and Restless Legs Syndrome: A Review of Current Literature.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Review
- Restless legs syndrome: An overview of pathophysiology, comorbidities and therapeutic approaches (Review).Experimental and therapeutic medicine · 2022Review
- Association between thyroid function and disease severity in restless legs syndrome.Frontiers in neurology · 2022Article
- Sleep medicine: Practice, challenges and new frontiers.Frontiers in neurology · 2022Review
- Correlation between vitamin D and poor sleep status in restless legs syndrome.Frontiers in endocrinology · 2022Article
- Prevalence of Restless Legs Syndrome and its Symptoms among Patients with Spinal Disorders.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome is a common but still underdiagnosed neurologic disorder, characterized by peculiar symptoms typically occurring in the evening and at night, and resulting in sleep disruption and daily functioning impairment. This disease can affect subjects of all age ranges and of both sexes, manifesting itself with a broad spectrum of severity and deserving special attention in certain patient categories, in order to achieve a correct diagnosis and an effective treatment. The diagnosis of restless legs syndrome can be challenging in some patients, especially children and elderly people, and an effective treatment might be far from being easy to achieve after some years of drug therapy, notably when dopaminergic agents are used. Moreover, the pathophysiology of this disorder offers an interesting example of interaction between genetics and the environment, considering strong iron metabolism involvement and its interaction with recognized individual genetic factors. Therefore, this syndrome allows clinicians to verify how lifespan and time can modify diagnosis and treatment of a neurological disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.