Evidence map›Paper›PMID 32456040›Full record

ReviewMicromachines2020

Recent Advances in Electrochemiluminescence-Based Systems for Mammalian Cell Analysis.

Kaoru Hiramoto, Elena Villani, Tomoki Iwama, Keika Komatsu, Shinsuke Inagi, Kumi Y Inoue, Yuji Nashimoto, Kosuke Ino, Hitoshi Shiku

Open access · goldAbstract readReview
In one paragraph

Review in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 54 citations in OpenAlex.

  1. Recent advances in electrochemiluminescence sensing for in vitro cell analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  2. Article
  3. Review
  4. Electrochemiluminescence Sensor Based on CeOMolecules (Basel, Switzerland) · 2023
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Kaoru HiramotoGraduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan.
Elena VillaniDepartment of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Yokohama 226-8502, Japan.
Tomoki IwamaGraduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan.
Keika KomatsuGraduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan.
Shinsuke InagiDepartment of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, Yokohama 226-8502, Japan.
Kumi Y InoueGraduate School of Environmental Studies, Tohoku University, Sendai 980-8579, Japan.
Yuji NashimotoGraduate School of Engineering, Tohoku University, Sendai 980-8579, Japan.
Kosuke InoGraduate School of Engineering, Tohoku University, Sendai 980-8579, Japan.
Hitoshi ShikuGraduate School of Engineering, Tohoku University, Sendai 980-8579, Japan.
Tohoku University · JPTokyo Institute of Technology · JP

Funding

Japan Society for the Promotion of Science 18H01840, 18H01999, 19K20658, 19K05687, 19J20709, JP19F19769, and 20J21401Kato Foundation for Promotion for Science N/ANakatani Foundation N/AProgram for Creation of Interdisciplinary Research from the Frontier Research Institute for Interdisciplinary Sciences, Tohoku University N/AShimadzu Science Foundation N/A
6 · The paper itself

Abstract

Mammalian cell analysis is essential in the context of both fundamental studies and clinical applications. Among the various techniques available for cell analysis, electrochemiluminescence (ECL) has attracted significant attention due to its integration of both electrochemical and spectroscopic methods. In this review, we summarize recent advances in the ECL-based systems developed for mammalian cell analysis. The review begins with a summary of the developments in luminophores that opened the door to ECL applications for biological samples. Secondly, ECL-based imaging systems are introduced as an emerging technique to visualize single-cell morphologies and intracellular molecules. In the subsequent section, the ECL sensors developed in the past decade are summarized, the use of which made the highly sensitive detection of cell-derived molecules possible. Although ECL immunoassays are well developed in terms of commercial use, the sensing of biomolecules at a single-cell level remains a challenge. Emphasis is therefore placed on ECL sensors that directly detect cellular molecules from small portions of cells or even single cells. Finally, the development of bipolar electrode devices for ECL cell assays is introduced. To conclude, the direction of research in this field and its application prospects are described.

Indexed as

ECL luminophoreelectrochemical deviceelectrochemical microscopyelectrochemiluminescence (ECL)mammalian cell analysissingle-cell analysis

Identifiers

PMID32456040
PMCPMC7281524
OpenAlexW3027486628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.