Evidence map›Paper›PMID 32455939›Full record

ArticleViruses2020

Polyinosinic: Polycytidylic Acid and Murine Cytomegalovirus Modulate Expression of Murine IL-10 and IL-21 in White Adipose Tissue.

Pablo Garcia-Valtanen, Ruth Marian Guzman-Genuino, John D Hayball, Kerrilyn R Diener

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Pablo Garcia-ValtanenExperimental Therapeutics Laboratory, UniSA Cancer Research Institute, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.ORCID 0000-0003-4382-6446
Ruth Marian Guzman-GenuinoExperimental Therapeutics Laboratory, UniSA Cancer Research Institute, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.ORCID 0000-0002-7366-3644
John D HayballExperimental Therapeutics Laboratory, UniSA Cancer Research Institute, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
Kerrilyn R DienerExperimental Therapeutics Laboratory, UniSA Cancer Research Institute, Clinical and Health Sciences, University of South Australia, Adelaide 5000, Australia.
University of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White adipose tissue (WAT) produces interleukin-10 and other immune suppressors in response to pathogen-associated molecular patterns (PAMPs). It also homes a subset of B-cells specialized in the production of IL-10, referred to as regulatory B-cells. We investigated whether viral stimuli, polyinosinic: polycytidylic acid (poly(I:C)) or whole replicative murine cytomegalovirus (MCMV), could stimulate the expression of IL-10 in murine WAT using in vivo and ex vivo approaches. Our results showed that in vivo responses to systemic administration of poly(I:C) resulted in high levels of endogenously-produced IL-10 and IL-21 in WAT. In ex vivo WAT explants, a subset of B-cells increased their endogenous IL-10 expression in response to poly(I:C). Finally, MCMV replication in WAT explants resulted in decreased IL-10 levels, opposite to the effect seen with poly(I:C). Moreover, downregulation of IL-10 correlated with relatively lower number of Bregs. To our knowledge, this is the first report of IL-10 expression by WAT and WAT-associated B-cells in response to viral stimuli.

Indexed as

3T3 CellsAdipose Tissue, WhiteAnimalsCytokinesFemaleInterleukin-10Interleukin-21InterleukinsMiceMice, Inbred C57BLMice, KnockoutMuromegalovirusPoly I-CToll-Like Receptor 3CytokinesInterleukin-10Interleukin-21InterleukinsPoly I-CTLR3 protein, mouseToll-Like Receptor 3interleukin-10Murine cytomegaloviruspolyinosinic: polycytidylic acidregulatory B-cellswhite adipose tissue

Identifiers

PMID32455939
PMCPMC7290755
OpenAlexW3026892994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.