Evidence map›Paper›PMID 32455937›Full record

ArticleJournal of clinical medicine2020

Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome.

Miho Nishitani-Yokoyama, Katsumi Miyauchi, Kazunori Shimada, Takayuki Yokoyama, Shohei Ouchi, Tatsuro Aikawa, Mitsuhiro Kunimoto, Miki Yamada, Akio Honzawa, Shinya Okazaki and 3 more

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In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Miho Nishitani-YokoyamaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Katsumi MiyauchiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Kazunori ShimadaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Takayuki YokoyamaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Shohei OuchiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Tatsuro AikawaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Mitsuhiro KunimotoDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Miki YamadaCardiovascular Rehabilitation and Fitness, Juntendo University Hospital, Tokyo 113-8431, Japan.
Akio HonzawaCardiovascular Rehabilitation and Fitness, Juntendo University Hospital, Tokyo 113-8431, Japan.
Shinya OkazakiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Hiroaki TsujitaDepartment of Medicine, Division of Cardiology, School of Medicine, Showa University, Tokyo 142-8666, Japan.
Shinji KobaDepartment of Medicine, Division of Cardiology, School of Medicine, Showa University, Tokyo 142-8666, Japan.
Hiroyuki DaidaDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Juntendo University · JPJuntendo University Hospital · JPShowa University · JP

Funding

MEXT (Ministry of Education, Culture, Sports, Science and Technology)-Supported Program for the Strategic Research Foundation at Private Universities, Japan and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Ja C-2159091, 15K09128
6 · The paper itself

Abstract

backgroundWe investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis.

methodsWe retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA.

resultsThe baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level.

conclusionsCombined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS.

Indexed as

achievement of LDL-C targetacute coronary syndromecardiac rehabilitationcoronary plaque regressionintegrated backscatter intravascular ultrasoundphysical activity

Identifiers

PMID32455937
PMCPMC7290587
OpenAlexW3026174565

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.