Evidence map›Paper›PMID 32455888›Full record

ArticleMicroorganisms2020

Phage Display Detection of Mimotopes that Are Shared Epitopes of Clinically and Epidemiologically Relevant Enterobacteria.

Armando Navarro, Delia Licona-Moreno, Alejandro Monsalvo-Reyes, Ulises Hernández-Chiñas, Carlos A Eslava-Campos

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In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Armando NavarroDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México City CP 04510, Mexico.
Delia Licona-MorenoDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México City CP 04510, Mexico.
Alejandro Monsalvo-ReyesLaboratorio de Bioquímica Molecular, Unidad de Biología y Prototipos, UBIPRO, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Reyes Ixtacala Tlalnepantla, Estado de México P C 54090, Mexico.
Ulises Hernández-ChiñasDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México City CP 04510, Mexico.ORCID 0000-0003-4708-8807
Carlos A Eslava-CamposDepartamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México City CP 04510, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

aimUsing phage display, the aim of this study is to identify mimotopes of shared epitopes in different enterobacterial LPSs.

methodsWe use anti-LPS IgG from

resultsFrom the last biopanning phase, sixty phagotopes are selected. The analysis of the peptide mimotope amino acid sequences shows that in 4 of them the S/N/A/PF motif is a common sequence. Antibodies from the sera of immunized rabbits with SP287/3, SP459/1, SP308/3, and SP073/14 react against both their own peptide and the different LPSs. The Western blot test shows a sera reaction against both the lateral chains and the cores of the LPSs. The analysis of the human sera shows a response against the SPs and LPSs.

conclusionThe designed synthetic peptides are mimotopes of LPS epitopes of

Indexed as

E. coliepitopesimmunogenic peptideslipopolysaccharidemimotopesphage displayphagotopesSalmonellasynthetic peptides

Identifiers

PMID32455888
PMCPMC7285282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.