Evidence map›Paper›PMID 32455807›Full record

ArticleJournal of clinical medicine2020

The COVID-19 Infection in Italy: A Statistical Study of an Abnormally Severe Disease.

Giuseppe De Natale, Valerio Ricciardi, Gabriele De Luca, Dario De Natale, Giovanni Di Meglio, Antonio Ferragamo, Vito Marchitelli, Andrea Piccolo, Antonio Scala, Renato Somma and 2 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Retrospective Analyses of COVID-19 and Population Ageing Effects on Italian Mortality during the Pandemic.International journal of environmental research and public health · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Underdetection in a stochastic SIR model for the analysis of the COVID-19 Italian epidemic.Stochastic environmental research and risk assessment : research journal · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. A simple but complex enoughPhysica D. Nonlinear phenomena · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giuseppe De NataleINGV, Osservatorio Vesuviano, 80124 Naples, Italy.ORCID 0000-0001-8391-2846
Valerio RicciardiDipartimento di Medicina Sperimentale, Università della Campania 'L.Vanvitelli', 80138 Naples, Italy.
Gabriele De LucaDepartment of Physics, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0003-3757-3761
Dario De NataleCoronaVerus, 80136 Naples, Italy.
Giovanni Di MeglioCoronaVerus, 80136 Naples, Italy.
Antonio FerragamoCoronaVerus, 80136 Naples, Italy.
Vito MarchitelliDepartment Mobility, Pub. Works, Ecology, Env, Puglia Region Government, 70100 Bari, Italy.
Andrea PiccoloCoronaVerus, 80136 Naples, Italy.
Antonio ScalaDepartment of Physics "Ettore Pancini", Università degli Studi di Napoli "Federico II", 80126 Naples, Italy.
Renato SommaINGV, Osservatorio Vesuviano, 80124 Naples, Italy.ORCID 0000-0002-2227-6054
Emanuele SpinaDepartment of Neurosciences, Reproductive and Odontostomatology, Università degli Studi di Napoli "Federico II", 80131 Naples, Italy.
Claudia TroiseINGV, Osservatorio Vesuviano, 80124 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We statistically investigate the Coronavirus Disease 19 (COVID-19) pandemic, which became particularly invasive in Italy in March 2020. We show that the high apparent lethality or case fatality ratio (CFR) observed in Italy, as compared with other countries, is likely biased by a strong underestimation of the number of infection cases. To give a more realistic estimate of the lethality of COVID-19, we use the actual (March 2020) estimates of the infection fatality ratio (IFR) of the pandemic based on the minimum observed CFR and analyze data obtained from the Diamond Princess cruise ship, a good representation of a "laboratory" case-study from an isolated system in which all the people have been tested. From such analyses, we derive more realistic estimates of the real extent of the infection as well as more accurate indicators of how fast the infection propagates. We then isolate the dominant factors causing the abnormal severity of the disease in Italy. Finally, we use the death count-the only data estimated to be reliable enough-to predict the total number of people infected and the interval of time when the infection in Italy could end.

Indexed as

COVID-19epidemic in Italystatistical forecast

Identifiers

PMID32455807
PMCPMC7291160

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.