Evidence map›Paper›PMID 32455751›Full record

ArticleMetabolites2020

Impact of Pre-blood Collection Factors on Plasma Metabolomic Profiles.

Sheetal Hardikar, Richard D Albrechtsen, David Achaintre, Tengda Lin, Svenja Pauleck, Mary Playdon, Andreana N Holowatyj, Biljana Gigic, Petra Schrotz-King, Juergen Boehm and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in Metabolites, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sheetal HardikarPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Richard D AlbrechtsenPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
David AchaintreInternational Agency for Research on Cancer, 69372 Lyon, France.
Tengda LinPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Svenja PauleckPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Mary PlaydonPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Andreana N HolowatyjPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Biljana GigicDepartment of Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
Petra Schrotz-KingDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Juergen BoehmPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Nina HabermannDivision of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stefanie BrezinaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, 1090 Vienna, Austria.
Eline H van RoekelDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The Netherlands.
Matty P WeijenbergDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, 6211 LK Maastricht, The Netherlands.
Pekka Keski-RahkonenInternational Agency for Research on Cancer, 69372 Lyon, France.
Augustin ScalbertInternational Agency for Research on Cancer, 69372 Lyon, France.
Jennifer OsePopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.
Cornelia M UlrichPopulation Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA.

Funding

Transdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6M
Discovery and verification of novel biomarkers of colorectal cancer recurrenceR01CA189184 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2015 to 2020
$5.6M
Metabolomic Strategies for Discovery and Validation of Biomarkers of Colorectal Cancer RecurrenceR01CA207371 · NCI · UNIVERSITY OF UTAH · PI LI, CHRISTOPHER I, ULRICH, CORNELIA M · 2017 to 2022
$3.9M
Diabetes, Medications and the Cost-Effectiveness of Screening for Colorectal NeoplasiaK07CA222060 · NCI · UNIVERSITY OF UTAH · PI HARDIKAR, SHEETAL · 2018 to 2022
$791k
NCI NIH HHS K07 CA222060NCI NIH HHS R01 CA189184, R01 CA207371, and U01 CA206110NCI NIH HHS R01 CA207371NCI NIH HHS U01 CA206110World Health Organization 001
6 · The paper itself

Abstract

Demographic, lifestyle and biospecimen-related factors at the time of blood collection can influence metabolite levels in epidemiological studies. Identifying the major influences on metabolite concentrations is critical to designing appropriate sample collection protocols and considering covariate adjustment in metabolomics analyses. We examined the association of age, sex, and other short-term pre-blood collection factors (time of day, season, fasting duration, physical activity, NSAID use, smoking and alcohol consumption in the days prior to collection) with 133 targeted plasma metabolites (acylcarnitines, amino acids, biogenic amines, sphingolipids, glycerophospholipids, and hexoses) among 108 individuals that reported exposures within 48 h before collection. The differences in mean metabolite concentrations were assessed between groups based on pre-collection factors using two-sided

Indexed as

agealcoholblood collectionconfoundingmetabolitesmetabolomicsNSAIDphysical activityprocessingsample handlingsexsmoking

Identifiers

PMID32455751
PMCPMC7281389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.