Evidence map›Paper›PMID 32455614›Full record

ArticleInternational journal of molecular sciences2020

KRAB-Induced Heterochromatin Effectively Silences

Rutger A F Gjaltema, Désirée Goubert, Christian Huisman, Consuelo Del Pilar García Tobilla, Mihály Koncz, Pytrick G Jellema, Dandan Wu, Uilke Brouwer, Antal Kiss, Pernette J Verschure and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Rutger A F GjaltemaEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Désirée GoubertEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Christian HuismanEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Consuelo Del Pilar García TobillaEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Mihály KonczInstitute of Biochemistry, Biological Research Centre, H-6726 Szeged, Hungary.
Pytrick G JellemaEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Dandan WuEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-8515-2614
Uilke BrouwerEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.
Antal KissInstitute of Biochemistry, Biological Research Centre, H-6726 Szeged, Hungary.ORCID 0000-0002-7975-3085
Pernette J VerschureSwammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.ORCID 0000-0003-2922-4836
Ruud A BankMATRIX Research Group, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Marianne G RotsEpigenetic Editing Laboratory, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1 EA11, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-7416-2788
University Medical Center Groningen · NLHUN-REN Szegedi Biológiai Kutatóközpont · HUUniversity of Amsterdam · NLUniversity of Szeged · HU

Funding

Horizon 2020 H2020-MSCA-ITN-2014-ETN 642691Nederlandse Organisatie voor Wetenschappelijk Onderzoek 91786373Netherlands Institute of Government FES0908ZonMw 40-00506-98-9021
6 · The paper itself

Abstract

Epigenetic editing, an emerging technique used for the modulation of gene expression in mammalian cells, is a promising strategy to correct disease-related gene expression. Although epigenetic reprogramming results in sustained transcriptional modulation in several in vivo models, further studies are needed to develop this approach into a straightforward technology for effective and specific interventions. Important goals of current research efforts are understanding the context-dependency of successful epigenetic editing and finding the most effective epigenetic effector(s) for specific tasks. Here we tested whether the fibrosis- and cancer-associated

Indexed as

Gene SilencingAdultCells, CulturedDNA-Cytosine MethylasesEpigenesis, GeneticHEK293 CellsHeterochromatinHumansKruppel-Like Transcription FactorsMCF-7 CellsProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenasePromoter Regions, GeneticTranscriptional ActivationTransforming Growth Factor betaDNA-Cytosine MethylasesDNA modification methylase SssIHeterochromatinKruppel-Like Transcription FactorsPLOD2 protein, humanProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseTransforming Growth Factor betacancerepigenetic editingfibrosisgene repressionKRABPLOD2

Identifiers

PMID32455614
PMCPMC7279273
OpenAlexW3026294864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.