Evidence map›Paper›PMID 32455556›Full record

ArticleJournal of clinical medicine2020

Prevalence and Correlates of Lymphatic Filariasis Infection and Its Morbidity Following Mass Ivermectin and Albendazole Administration in Mkinga District, North-Eastern Tanzania.

Adam M Fimbo, Omary M S Minzi, Bruno P Mmbando, Abbie Barry, Alex F Nkayamba, Kissa W Mwamwitwa, Alpha Malishee, Misago D Seth, Williams H Makunde, Parthasarathi Gurumurthy and 3 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.The journal of venomous animals and toxins including tropical diseases · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adam M FimboDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, 141 86 Huddinge, Sweden.
Omary M S MinziDepartment of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, P.O. Box 65001, Tanzania.
Bruno P MmbandoNational Institute for Medical Research, Tanga Center, Tanga, P.O. Box 5004, Tanzania.
Abbie BarryDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, 141 86 Huddinge, Sweden.ORCID 0000-0002-3859-3660
Alex F NkayambaTanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, P.O. Box 77150, Tanzania.
Kissa W MwamwitwaTanzania Medicines and Medical Devices Authority (TMDA), Dar es Salaam, P.O. Box 77150, Tanzania.
Alpha MalisheeNeglected Tropical Diseases Control Programme, Dar es Salaam 40478, P.O. Box 743, Tanzania.
Misago D SethNational Institute for Medical Research, Tanga Center, Tanga, P.O. Box 5004, Tanzania.ORCID 0000-0002-6743-4108
Williams H MakundeNational Institute for Medical Research, Tanga Center, Tanga, P.O. Box 5004, Tanzania.
Parthasarathi GurumurthyPharmacovigilance and Clinical Trials, Botswana Medicines Regulatory Authority, Gaborone 999106, Botswana.ORCID 0000-0002-5997-1157
John P A LusinguNational Institute for Medical Research, Tanga Center, Tanga, P.O. Box 5004, Tanzania.
Appolinary A R KamuhabwaDepartment of Clinical Pharmacy and Pharmacology, School of Pharmacy, Muhimbili University of Health and Allied Sciences, Dar es Salaam, P.O. Box 65001, Tanzania.
Eleni AklilluDivision of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, 141 86 Huddinge, Sweden.ORCID 0000-0002-9788-0790

Funding

European and Developing Countries Clinical Trials Partnership CSA2016S-1618
6 · The paper itself

Abstract

Lymphatic filariasis (LF) is a neglected tropical disease targeted for elimination as public health problem through morbidity management and preventive annual mass drug administration (MDA). This cross-sectional community-based surveillance assessed the prevalence and correlates of LF infection in Mkinga district, Tanga-region, Tanzania. A total of 4115 individuals (49.7% males, 35.2% children) were screened for circulating filarial antigens (CFA), microfilaremia (mf) and disease manifestations in 15 villages between November 2018 and January 2019. MDA uptake in the previous year was assessed. Overall prevalence of CFA-positivity was 5.8% (239/4115; 95% CI: 5.1-6.6), with significant heterogeneity between villages (range 1.2% to 13.5%). CFA-positivity was higher in males (8.8%) than females (3.3%), and correlated with increasing age (

Indexed as

albendazoleantigenemiacirculatingfilarial antigenivermectinlymphatic filariasismass drug administrationmicrofilaremiamicrofilariaeTangaWuchereria bancrofti

Identifiers

PMID32455556
PMCPMC7290598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.