ArticleJournal of Korean Neurosurgical Society2020
Comparison of Fusion Rate between Demineralized Bone Matrix versus Autograft in Lumbar Fusion : Meta-Analysis.
Article in Journal of Korean Neurosurgical Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Ceramic bone graft substitute vs autograft in XLIF: a prospective randomized single-center evaluation of radiographic and clinical outcomes.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Trial
- Advancements in biomaterials and bioactive solutions for lumbar spine fusion cages: Current trends and future perspectives.Bioactive materials · 2025Review
- Imaging indicators and fusion analysis of percutaneous endoscopic posterior lumbar interbody fusion and modified posterior lumbar interbody fusion for the treatment of lumbar degenerative diseases.Quantitative imaging in medicine and surgery · 2025Article
- Transforming spinal surgery with innovations in biologics and additive manufacturing.Materials today. Bio · 2025Review
- Rapid preparation of bioactive composites for transforaminal lumbar interbody fusion.Scientific reports · 2025Article
- Comparison of bone ingrowth and clinical outcome of a collagen-hydroxyapatite bone graft substitute versus autologous bone graft in posterior lumbar interbody fusion.Quantitative imaging in medicine and surgery · 2025Article
- Research Progress of Bone Grafting: A Comprehensive Review.International journal of nanomedicine · 2025Review
- High Lumbar Spinal Fusion Rates Using Cellular Bone Allograft Irrespective of Surgical Approach.International journal of spine surgery · 2024Article
- Effect of Mixture of Recombinant Human Bone Morphogenic Protein-2 and Demineralized Bone Matrix in Lateral Lumbar Interbody Fusion.Journal of Korean Neurosurgical Society · 2024Article
- Demineralized Bone Matrix and Fibers in Spinal Fusion.International journal of spine surgery · 2023Article
- Demineralized cortical fibers are associated with a low pseudarthrosis rate in patients undergoing surgery for adult spinal deformity without three-column osteotomy.Brain & spine · 2023Article
- Twelve-Month Results from a Prospective Clinical Study Evaluating the Efficacy and Safety of Cellular Bone Allograft in Subjects Undergoing Lumbar Spinal Fusion.Neurology international · 2022Article
- Novel Approaches Guiding the Future of Spinal Biologics for Bone Regeneration.Current reviews in musculoskeletal medicine · 2022Review
- Engineering Multifunctional Hydrogel With Osteogenic Capacity for Critical-Size Segmental Bone Defect Repair.Frontiers in bioengineering and biotechnology · 2022Article
- Therapeutics for enhancement of spinal fusion: A mini review.Journal of orthopaedic translation · 2021Review
- Demineralized Bone Matrix in Spine Surgery: A Review of Current Applications and Future Trends.International journal of spine surgery · 2021Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The demineralized bone matrix (DBM) as the bone graft material to increase the fusion rate was widely used in spinal fusion. The current study aimed to compare the fusion rate of DBM to the fusion rate of autograft in lumbar spine fusion via meta-analysis of published literature. After systematic search, comparative studies were selected according to eligibility criteria. Checklist (risk of bias assessment tool for non-randomized study) was used to evaluate the risk of bias of the included nonrandomized controlled studies. The corresponding 95% confidence interval (95% CI) were calculated. We also used subgroup analysis to analyze the fusion rate of posterolateral lumbar fusion and lumbar interbody fusion. Eight studies were finally included in this meta-analysis. These eight studies included 581 patients. Among them, 337 patients underwent spinal fusion surgery using DBM (DBM group) and 204 patients underwent spinal fusion surgery with mainly autologous bone and without using DBM (control group). There was no significant differences of fusion rate between the two groups in posterolateral fusion analysis (risk ratio [RR], 1.03; 95% CI, 0.90-1.17; p=0.66) and interbody fusion analysis (RR, 1.13; 95% CI, 0.91-1.39; p=0.27). Based on the available evidence, the use of DBM with autograft in posterolateral lumbar spine fusion and lumbar interbody fusion showed a slightly higher fusion rate than that of autograft alone; however, there was no statistically different between two groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.