Evidence map›Paper›PMID 32455139›Full record

ArticleJournal of immunology research2020

Probiotics Can Boost the Antitumor Immunity of CD8

Jie Mao, Shu-Ze Zhang, Peng Du, Zhi-Bin Cheng, Huan Hu, Shi-Yao Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Cells · 2026
    Article
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  8. Mechanism of probiotics in the intervention of colorectal cancer: a review.World journal of microbiology & biotechnology · 2024
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jie MaoThe Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030 Gansu, China.
Shu-Ze ZhangThe Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030 Gansu, China.
Peng DuThe Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030 Gansu, China.ORCID https://orcid.org/0000-0001-8478-054X
Zhi-Bin ChengThe Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030 Gansu, China.
Huan HuSecond Clinical Medical College, Lanzhou University, Lanzhou, 730030 Gansu, China.
Shi-Yao WangSecond Clinical Medical College, Lanzhou University, Lanzhou, 730030 Gansu, China.
Lanzhou University Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe drug resistance and the immune suppression in the tumor microenvironment are important factors affecting tumor progression. Reversing drug resistance and changing tumor suppression microenvironment are ideal ways to inhibit tumor progression.

objectiveThe aim of the study is to verify antitumor immune response of probiotics in patients with colorectal carcinoma and to explore its mechanism.

methodsTo detect the tumor samples of 122 patients with colorectal carcinoma after surgery, analyze the effect of probiotics on enhancing tumor-infiltrating CD8

resultsThe results of immunohistochemistry showed that the proportion of CD8

conclusionsProbiotics can enhance the antitumor immune response of CD8

Indexed as

AnimalsCarcinogenesisCD8-Positive T-LymphocytesCell Growth ProcessesCell Line, TumorColorectal NeoplasmsDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansImmunityLymphocytes, Tumor-InfiltratingMaleMiceMice, Inbred BALB CNeoplasm StagingPdcd1 protein, mouseProgrammed Cell Death 1 Receptor

Identifiers

PMID32455139
PMCPMC7232718
OpenAlexW3023517774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.