ReviewAdvances in orthopedics2020
Role of Platelet-Rich Plasma in Spinal Fusion Surgery: Systematic Review and Meta-Analysis.
Review in Advances in orthopedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery.Scientific reports · 2022Pooled it
- A study on the effect of platelet-rich plasma (PRP) to promote bone fusion in lateral interbody fusion of the lumbar spine using artificial bone.Journal of orthopaedic surgery and research · 2024Trial
- Bone Growth Stimulators to Enhance Spinal Fusion Outcomes.Spine surgery and related research · 2026Review
- Review
- Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries.Regenerative medicine · 2024Review
- A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing.Cureus · 2024Review
- Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview.Spine surgery and related research · 2024Review
- Bone Grafting Options for Single-Level TLIF: So Many Options, What Is the Evidence?International journal of spine surgery · 2023Article
- Combined effect of DBM, PRP, and bone marrow fluid on bone union in a rat posterolateral fusion model.Scientific reports · 2023Article
- Application of platelet-rich plasma in spinal surgery.Frontiers in endocrinology · 2023Review
- Article
- Is Platelet-Rich Plasma Effective in Enhancing Spinal Fusion? Systematic Overview of Overlapping Meta-Analyses.Global spine journal · 2022Article
- The efficacy of platelet-rich plasma applicated in spinal fusion surgery: A meta-analysis.Frontiers in surgery · 2022Review
- Therapeutics for enhancement of spinal fusion: A mini review.Journal of orthopaedic translation · 2021Review
- Understanding the Future Prospects of Synergizing Minimally Invasive Transforaminal Lumbar Interbody Fusion Surgery with Ceramics and Regenerative Cellular Therapies.International journal of molecular sciences · 2021Review
- Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet-rich plasma (PRP) has been used very successfully in enhancing bone fusion in animal experiments. Also, the efficaciousness of PRP in other specialties of medicine such as dentistry, dermatology ophthalmology, and sports medicine is well documented. But the use of PRP to augment bone fusion after spinal surgery in humans is still controversial. We conducted a meta-analysis to determine the role of PRP in enhancing spinal fusion by fastening the rate of new bone formation and decreasing pain after spinal surgery in humans.
methodsWe searched PubMed, EMBASE, and the Cochrane Library studies that compared PRP versus control in enhancing spinal fusion after deformity correction.
resultsFive retrospective studies with 253 participants and nine prospective cohort studies with 460 participants were identified. The bone fusion rate was excellent for studies that used a high platelet concentration in PRP relative to control (odds ratio (OR) = 4.35, 95% confidence interval (CI) (2.13, 8.83), and
conclusionPRP facilitates new bone formation and bone fusion with a minimum concentration of the growth factor 5 times that of the peripheral blood. PRP stimulatory effects are not continuous and are very effective within six months of implantation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.