ArticleOxidative medicine and cellular longevity2020
Regulation on Calcium Oxalate Crystallization and Protection on HK-2 Cells of Tea Polysaccharides with Different Molecular Weights.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
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- Preparation, Characterization and Bioactivities of Strawberry Polysaccharides.Foods (Basel, Switzerland) · 2025Article
- Comparative Study of the Structural Characteristics and Bioactivity of Polysaccharides Extracted fromMolecules (Basel, Switzerland) · 2023Article
- Antioxidant Activity ofBioinorganic chemistry and applications · 2023Article
- A Review on the Extraction, Bioactivity, and Application of Tea Polysaccharides.Molecules (Basel, Switzerland) · 2022Review
- Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides FromFrontiers in pharmacology · 2022Article
- Formation and Characterization of Irreversible Sediment of Ginseng Extract.Foods (Basel, Switzerland) · 2021Article
- Inhibition of Calcium Oxalate Formation and Antioxidant Activity of CarboxymethylatedOxidative medicine and cellular longevity · 2021Article
- Article
- Protective Effect of DegradedOxidative medicine and cellular longevity · 2021Article
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4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The regulation on calcium oxalate (CaOx) crystallization and protective effect on human proximal tubular epithelial cells (HK-2) of four green tea polysaccharides (TPSs) with molecular weights of 10.88 (TPS0), 8.16 (TPS1), 4.82 (TPS2), and 2.3 kDa (TPS3) were comparatively studied. XRD, Fourier transform infrared spectroscopy, and scanning electron microscopy results revealed that TPS1, TPS2, and TPS3 can increase the percentage of the dihydrate crystalline phase in CaOx crystals and reduce the size of CaOx monohydrate crystals. TPSs increased the absolute value of the zeta potential of CaOx crystal and inhibited crystal nucleation and aggregation. The nucleation inhibition rates of TPS1, TPS2, and TPS3 to CaOx crystallization were 56.67%, 75.52%, and 52.92%, respectively, and their aggregation inhibition rates were 22.34%, 47.59%, and 21.59%, respectively. TPS preprotection can alleviate the oxidative damage of HK-2 cells caused by oxalate, increase cell viability, protect cell morphology, and reduce lactate dehydrogenase release and reactive oxygen species levels. The degraded TSPs, especially TPS2 with moderate molecular weight, may be used as a green drug to inhibit stone formation.
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