ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2020
Risk Factors Associated with Fatal Dengue Hemorrhagic Fever in Adults: A Case Control Study.
Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis.BMC infectious diseases · 2023Pooled it
- Genomic investigation reveals local persistence and regional circulation of dengue virus associated with recent outbreaks in Kenya.Scientific reports · 2026Article
- Risk factors associated with dengue lethality: case-control study, Joinville, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2026Article
- Transient Expression of Zika NS2B Protein Antigen inACS omega · 2025Article
- Application of multi-criteria decision analysis techniques and decision support framework for informing arbovirus risk assessments for planning, preparedness and response.Frontiers in bioengineering and biotechnology · 2025Article
- Evaluation of clinical and laboratory characteristics of dengue viral infection and risk factors of dengue hemorrhagic fever: a multi-center retrospective analysis.BMC infectious diseases · 2024Article
- Predictors of Mortality in Patients With Dengue Fever: Insights From a Comparative Analysis.Cureus · 2023Article
- Relationship between clinical and laboratory features with infecting dengue virus serotypes in a sample of dengue suspected adult patients from 2015-2017 in Sri Lanka.Journal of clinical virology plus · 2022Article
- Social, health system and clinical determinants of fever mortality during an outbreak of dengue fever in Kerala, India.Journal of family medicine and primary care · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is endemic in most parts of the tropics with a significant mortality of 1-5%. Although individual case reports and case series have been published, large-scale case controls studies are few. The objective of this study was to find clinical and laboratory predictors of mortality in dengue.
methodsHospital case record based case control study was performed.
resultsTwenty fatalities with 80 controls were analyzed. Clinical parameters of postural dizziness (OR 3.2; 95% CI 1.1-8.9), bleeding (OR 31.9; 95% CI 6.08-167.34), presence of plasma leakage (OR 64.6; 95% CI 7.45-560.5), abdominal tenderness (OR 2.24; 95% CI 0.79-6.38), and signs of cardiorespiratory instability at admission increased the risk of dying from dengue. Altered consciousness was exclusively seen in 20% of cases. Laboratory parameters of elevated CRP (OR 1.652; 95% CI 1.28-2.14), AST, or ALT > 500 IU/L (OR 52.5; 95% CI 12.52-220.1) and acute kidney injury (AKI) (OR 103.5; 95% CI 13.26-807.78) during hospital stay increased the odds of dying. Need for assisted ventilation and multiorgan dysfunction (MOD) were exclusively seen in the cases. Multivariate logistic regression revealed bleeding at admission, AKI, and elevated hepatic transaminase >500 IU/L to be independent predictors of mortality.
conclusionsThis case control study revealed that mortality from dengue could be predicted using clinical parameters at admission and low cost routine laboratory investigations.
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