ArticleTurkish journal of pharmaceutical sciences2020
Anti-inflammatory Effects of Deuterium-Depleted Water Plus
Article in Turkish journal of pharmaceutical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Deuterium-depleted water inhibits the malignant progression of colorectal cancer cells by modulating oxidative stress.Oncology reports · 2025Article
- Phytochemical and Toxicological Analyses of Herbal Mixtures ContainingTurkish journal of pharmaceutical sciences · 2024Article
- Pharmaceutical Potential Evaluation of Damask Rose By-Products from Volatile Oil Extraction.Plants (Basel, Switzerland) · 2024Article
- Do Abiotic Stresses Affect the Aroma of Damask Roses?Plants (Basel, Switzerland) · 2023Review
- Comparative In Vitro and In Silico Enzyme Inhibitory Screening ofPlants (Basel, Switzerland) · 2023Article
- Phytochemical and biological activities of some Iranian medicinal plants.Pharmaceutical biology · 2022Review
- Effects of the hydroalcoholic extract of Rosa damascena on hippocampal long-term potentiation in rats fed high-fat diet.The journal of physiological sciences : JPS · 2021Article
- A Systematic Study of the Mechanism of Acacetin Against Sepsis Based on Network Pharmacology and Experimental Validation.Frontiers in pharmacology · 2021Article
- Article
- Inequality in the Frequency of the Open States Occurrence Depends on SingleMolecules (Basel, Switzerland) · 2020Article
- Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2.Pharmaceutical biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNatural medicine has been proposed for treating sepsis worldwide. Therefore, in this study, the effect of deuterium-depleted water (DDW) alone and adjuvant with MATERIALS AND
methodsThe rats were randomly divided into 5 groups: 1) laparotomy group; 2) cecal ligation and puncture (CLP) group; 3) DDW (15 ppm and 30 ppm doses) group; 4) DDW (15 ppm and 30 ppm doses) plus RD essential oil (100 mg/kg.bw); 5) indomethacin (2 mg/kg.bw) as a positive control. The treatments were daily administrated for 2 weeks and the CLP model was created on the day 15. Then, the animals were killed and their liver tissue was separated for histopathologic and biochemical assessment.
resultsOur results demonstrated that the treatment of animals with DDW and DDW plus RD essential oil was effective due to the regulation of the oxidative stress-antioxidant parameters including lipid peroxidation, glutathione (GSH), GSH s-transferases, myeloperoxidase, ferric reducing ability of plasma and inflammatory parameters such as prostaglandin E2 and COX-2. Pathological studies also showed that sepsis led to the liver tissue injuries, which can be reduced by treatments.
conclusionSepsis caused oxidative stress in the liver tissue, but the administration of DDW and DDW plus RD essential oil can be useful to prevent and heal these injuries.
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