ArticleTurkish journal of pharmaceutical sciences2019
Phytochemical Screening and Metallic Ion Content and Its Impact on the Antipsoriasis Activity of Aqueous Leaf Extracts of
Article in Turkish journal of pharmaceutical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Nanophytosomal Gel ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Dermal Delivery ofRecent advances in drug delivery and formulation · 2024Article
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Authors and funding
3 authors.
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Abstract
objectivesThe aim of this study was to evaluate the influence of metal ions present in soil as well as in leaf samples of MATERIALS AND
methodsTo meet the objective, soil and leaf samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in antipsoriatic activity. Thereafter imiquimod-induced dermatitis lesions were created in grouped mice. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used. Psoriasis severity index (PSI) was evaluated according to the phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity.
resultsWe observed redness, erythema, and scales and the histological features and found a progressive reduction (P<0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from days 7 to 21 and decreased epidermal thickness in animals treated with combined extracts at a dose of 200 mg/kg b.w. Furthermore, plant samples procured from the Nandi Hills, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg), and Zn (1.12 mg/kg), which showed a positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicating a significant reduction in psoriatic lesions.
conclusionThe results revealed that the significant dose-dependent antipsoriasis activity of combined aqueous extracts of
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