ArticleTurkish journal of pharmaceutical sciences2019
Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin.
Article in Turkish journal of pharmaceutical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Role of curcumin in ischemia and reperfusion injury.Frontiers in pharmacology · 2023Review
- Types and Severity of Hearing Loss among Patients with Tuberculosis receiving Anti-Tuberculosis Treatment in Nigeria: A Single Center Study.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
objectivesMicrocirculation and hemodynamic disturbances, including in the cochlea, are commonly found in diabetic patients. A study on diabetic rats discovered histopathological changes in outer hair cells and the spiral ganglion and mitochondrial damage in the ear. Hyperglycemia can increase the activation of protein kinase C (PKC). Curcumin as an antioxidant also affects the regulation of PKC and Ca MATERIALS AND
methodsAn experimental study was performed on 24 Wistar rats divided into the following 6 groups: group 1: control group; group 2: diabetic group without curcumin administration; groups 3 and 4: diabetic groups with curcumin administration (200 mg/kg and 400 mg/kg for 3 days, respectively); groups 5 and 6: diabetic groups with curcumin administration (200 mg/kg and 400 mg/kg for 8 days, respectively). Cochlear tissues were taken from all groups and immunohistochemistry-stained, and the PKC expression scores were analyzed with one-way ANOVA (a significance level of 0.05).
resultsSignificant differences in PKC expression (p<0.05) were found between group 1 and group 2, and group 2 and groups 3, 4, 5, and 6. There was no significant difference in PKC expression regarding the different doses and the duration of curcumin administration.
conclusionCurcumin can reduce PKC expression in the cochlear fibroblasts of diabetic rats.
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