ArticleTurkish journal of pharmaceutical sciences2017
Adenosine A2B Receptors - Mediated Induction of Interleukin-6 in Skeletal Muscle Cells.
Article in Turkish journal of pharmaceutical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- APurinergic signalling · 2025Review
- Therapeutic Potential of Highly Selective AMolecules (Basel, Switzerland) · 2022Review
- The Impact of CB1 Receptor on Nuclear Receptors in Skeletal Muscle Cells.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- Impact of Adenosine Analogue, Adenosine-5'-N-Ethyluronamide (NECA), on Insulin Signaling in Skeletal Muscle Cells.BioMed research international · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
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Abstract
objectivesInflammatory response and cytokine activation are markedly stimulated in skeletal muscle during various conditions. Interleukin-6 (IL-6), a pro-inflammatory cytokine, has pleiotropic effects on skeletal muscle. Adenosine, released by all cell types, binds to a class of G protein-coupled receptors to induce various skeletal muscle effects. The aim of this work was to investigate whether activation of adenosine receptors, particularly adenosine A2B receptors, could stimulate IL-6 gene expression in rat L6 skeletal muscle cells. MATERIALS AND
methodsThe rat L6 skeletal muscle cells were cultured in 25 cm
resultsAdenosine-5'-
conclusionHere, a novel relationship between adenosine and IL-6 up-regulation has been demonstrated for the first time; IL-6 up-regulation induced by NECA is mediated by adenosine A2B receptor activation in skeletal muscle and is dependent on mainly a cAMP pathway. Adenosine A2B receptors are, thus, potentially important pharmacological targets in treating inflammation and related diseases in skeletal muscle tissues.
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