Evidence map›Paper›PMID 32454443›Full record

ArticleTranslational oncology2020

A Dodecapeptide Selected by Phage Display as a Potential Theranostic Probe for Colon Cancers.

Moon Hwa Kwak, Gawon Yi, Seung Mok Yang, Younghee Choe, Sangkee Choi, Hye-Soo Lee, Eunha Kim, Yong-Beom Lim, Kun Na, Myung-Gyu Choi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Imaging techniques in nanomedical research.European journal of histochemistry : EJH · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Moon Hwa KwakCatholic Photomedicine Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Gawon YiDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Seung Mok YangCatholic Photomedicine Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Younghee ChoeCatholic Photomedicine Research Institute, The Catholic University of Korea, Seoul, Republic of Korea.
Sangkee ChoiDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
Hye-Soo LeeDepartment of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea.
Eunha KimDepartment of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.
Yong-Beom LimDepartment of Materials Science and Engineering, Yonsei University, Seoul, Republic of Korea.
Kun NaDepartment of Biotechnology, The Catholic University of Korea, Seoul, Republic of Korea.
Myung-Gyu ChoiCatholic Photomedicine Research Institute, The Catholic University of Korea, Seoul, Republic of Korea; Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.
Heebeom KooDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: hbkoo@catholic.ac.kr.
Jae Myung ParkCatholic Photomedicine Research Institute, The Catholic University of Korea, Seoul, Republic of Korea; Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: parkjerry@catholic.ac.kr.
Catholic University of Korea · KRAjou University · KRSeoul St. Mary's Hospital · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimColon cancer is one of the leading causes of cancer-related mortality. However, specific biomarkers for its diagnosis or treatment are not established well.

methodsWe developed a colon-cancer specific peptide probe using phage display libraries. We validated the specificity of this probe to colon cancer cells with immunohistochemical staining and FACS analysis using one normal cell and five colon cancer cell lines.

resultsThis peptide probe maintained binding affinity even after serum incubation. For therapeutic applications, this peptide probe was conjugated to hematoporphyrin, a photosensitizer, which showed a significantly enhanced cellular uptake and high photodynamic effect to kill tumor cells. As another application, we made a nanoparticle modified from the peptide probe. It efficiently delivered SN-38, an anticancer drug, into tumor cells, and its tumor-targeting ability was observed in vivo after intravenous injection to the same xenograft model.

conclusionThe noble dodecapeptide probe can be a promising candidate for both colon tumor diagnosis and targeted drug delivery.

Identifiers

PMID32454443
PMCPMC7248426
OpenAlexW3026422809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.