Evidence map›Paper›PMID 32454319›Full record

ArticleJournal of the neurological sciences2020

Dysphagia in spinocerebellar ataxias type 1, 2, 3 and 6.

Chen-Ya Yang, Ruo-Yah Lai, Nadia Amokrane, Chi-Ying Lin, Karla P Figueroa, Stefan M Pulst, Susan Perlman, George Wilmot, Christopher M Gomez, Jeremy D Schmahmann and 12 more

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In one paragraph

Article in Journal of the neurological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Classifying neurogenic dysphagia as a movement disorder.Brain : a journal of neurology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Anxiety and depression in spinocerebellar ataxia patients during the COVID-19 pandemic in China: A cross-sectional study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 2 countries.

Chen-Ya YangDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA; Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Chiayi and Wanqiao Branch, Chiayi, Taiwan.
Ruo-Yah LaiDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA.
Nadia AmokraneDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA.
Chi-Ying LinDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA.
Karla P FigueroaDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Stefan M PulstDepartment of Neurology, University of Utah, Salt Lake City, UT, USA.
Susan PerlmanDepartment of Neurology, University of California Los Angeles, Los Angeles, CA, USA.
George WilmotDepartment of Neurology, Emory University, Atlanta, GA, USA.
Christopher M GomezDepartment of Neurology, University of Chicago, Chicago, IL, USA.
Jeremy D SchmahmannDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Henry PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Vikram G ShakkottaiDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Liana S RosenthalDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Sarah H YingDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Theresa ZesiewiczDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Khalaf BusharaDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Michael GeschwindDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Guangbin XiaDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
S H SubramonyDepartment of Neurology, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Tetsuo AshizawaHouston Methodist Research Institute, Houston, TX, USA.
Michelle S TrocheDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA; Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA.
Sheng-Han KuoDepartment of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Initiative for Columbia Ataxia and Tremor, Columbia University, New York, NY, USA. Electronic address: sk3295@cumc.columbia.edu.
Columbia University · USJohns Hopkins University · USUniversity of Michigan–Ann Arbor · USUniversity of Utah · USEmory University · USHarvard University · USHouston Methodist · USTaichung Veterans General Hospital · TWUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Florida · USUniversity of Minnesota · USUniversity of New Mexico · USUniversity of South Florida · US

Funding

Spinocerebellar Ataxia Type 2 Gene and Gene ProductR37NS033123 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M. · 2014 to 2020
$3.6M
Targeting Cerebellar Endoplasmic Reticulum Calcium Handling in Essential TremorR01NS124854 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHYLLIS L FAUST, Sheng-Han Kuo · 2022 to 2026
$2.9M
SPINOCEREBELLAR ATAXIA TYPE 2--GENE AND GENE PRODUCTR01NS033123 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M. · 1996 to 2012
$2.9M
Targeting Cerebellar Excitatory Synapses for Tremor ProgressionR01NS118179 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2020 to 2024
$2.2M
Cerebellar Circuitry in the Pathophysiology of TremorR01NS104423 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2018 to 2022
$2.0M
Antisense Oligonucleotides for treating Spinocerebellar Ataxia Type 2U01NS103883 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M., SCOLES, DANIEL R · 2018 to 2020
$1.9M
Clinical Research Consortium for Spinocerebellar AtaxiasRC1NS068897 · NINDS · UNIVERSITY OF FLORIDA · PI ASHIZAWA, TETSUO · 2009 to 2010
$1.0M
The role of glucocerebrosidase and chaperone_mediated autophagy in Parkinsons disK08NS083738 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2013 to 2017
$940k
Characterization of ATXN2 as a target for ALS in SCA2 motor neuronsR21NS103009 · NINDS · UNIVERSITY OF UTAH · PI PULST, STEFAN M., SCOLES, DANIEL R · 2018 to 2019
$419k
Dietary Contribution in Cerebellar AtaxiaR03NS114871 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KUO, SHENG-HAN · 2019 to 2020
$162k
NINDS NIH HHS K08 NS083738NINDS NIH HHS R01 NS033123NINDS NIH HHS R01 NS104423NINDS NIH HHS R01 NS118179NINDS NIH HHS R01 NS124854NINDS NIH HHS R03 NS114871NINDS NIH HHS R21 NS103009NINDS NIH HHS R37 NS033123NINDS NIH HHS RC1 NS068897NINDS NIH HHS U01 NS103883
6 · The paper itself

Abstract

backgroundDysphagia is a common symptom and may be a cause of death in patients with spinocerebellar ataxias (SCAs). However, little is known about at which disease stage dysphagia becomes clinically relevant. Therefore, our study aims to investigate the prevalence of dysphagia in different disease stages of SCA 1, 2, 3 and 6.

methodsWe studied 237 genetically confirmed patients with SCA 1, 2, 3, 6 from the Clinical Research Consortium for SCAs and investigated the prevalence of self-reported dysphagia and the association between dysphagia and other clinical characteristics. We further stratified ataxia severity and studied the prevalence of dysphagia at each disease stage.

resultsDysphagia was present in 59.9% of SCA patients. Patients with dysphagia had a longer disease duration and more severe ataxia than patients without dysphagia (patients with dysphagia vs. without dysphagia, disease duration (years): 14.51 ± 8.91 vs. 11.22 ± 7.82, p = .001, scale for the assessment and rating of ataxia [SARA]: 17.90 ± 7.74 vs. 13.04 ± 7.51, p = .000). Dysphagia was most common in SCA1, followed by SCA3, SCA 6, and SCA 2. Dysphagia in SCA1 and 3 was associated robustly with ataxia severity, whereas this association was less obvious in SCA2 and 6, demonstrating genotype-specific clinical variation.

conclusionDysphagia is a common clinical symptom in SCAs, especially in the severe disease stage. Understanding dysphagia in SCA patients can improve the care of these patients and advance knowledge on the roles of the cerebellum and brainstem control in swallowing.

Indexed as

Deglutition DisordersSpinocerebellar AtaxiasBrain StemHumansAspirationDeglutitionNeurodegenerative diseaseSpinocerebellar ataxia

Identifiers

PMID32454319
PMCPMC10150947
OpenAlexW3020856398

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.