Evidence map›Paper›PMID 32454259›Full record

Trial reportClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2021

An Unsuccessful Randomized Trial of Percutaneous vs Endoscopic Drainage of Suspected Malignant Hilar Obstruction.

B Joseph Elmunzer, Zachary L Smith, Paul Tarnasky, Andrew Y Wang, Patrick Yachimski, Filip Banovac, Jonathan M Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong and 18 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07558304 (Randomized Clinical Trial of Suprapapillary Drainage With Metal Stent vs. Routine Internal-External Transpapillary Drainage in Patients With Malignant Hilar Biliary Obstruction), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07558304 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Randomized Clinical Trial of Suprapapillary Drainage With Metal Stent vs. Routine Internal-External Transpapillary Drainage in Patients With Malignant Hilar Biliary Obstruction

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2026 to 2028Enrolled84ConditionsCholangiocarcinoma, Bile Duct Neoplasms, Malignant Biliary ObstructionArmsPercutaneous transpapillary internal-external biliary drainage, Percutaneous suprapapillary biliary drainage with self-expanding metal stent
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

B Joseph ElmunzerDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address: elmunzer@musc.edu.
Zachary L SmithDivision of Gastroenterology and Liver Disease, Case Western Reserve University, Cleveland, Ohio.
Paul TarnaskyDivision of Gastroenterology, Methodist Dallas Medical Center, Dallas, Texas.
Andrew Y WangDivision of Gastroenterology and Hepatology, University of Virginia, Charlottesville, Virginia.
Patrick YachimskiDivision of Gastroenterology, Vanderbilt University, Nashville, Tennessee.
Filip BanovacDivision of Interventional Radiology, Vanderbilt University, Nashville, Tennessee.
Jonathan M BuscagliaDivision of Gastroenterology, Stony Brook University, Stony Brook, New York.
James BuxbaumDivision of Gastroenterology, University of Southern California, Los Angeles, California.
Amitabh ChakDivision of Gastroenterology and Liver Disease, Case Western Reserve University, Cleveland, Ohio.
Bradford ChongDivision of Gastroenterology, University of Southern California, Los Angeles, California.
Gregory A CotéDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina.
Peter V DraganovDivision of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida.
Kulwinder DuaDivision of Gastroenterology, Medical College of Wisconsin, Milwaukee, Wisconsin.
Valerie DurkalskiDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Brian S GellerDivision of Interventional Radiology, University of Florida, Gainesville, Florida.
Laith H JamilDivision of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, California.
Rajesh N KeswaniDivision of Gastroenterology, Northwestern University, Chicago, Illinois.
Mouen A KhashabDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Ryan LawDivision of Gastroenterology, University of Michigan, Ann Arbor, Michigan.
Simon K LoDivision of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, California.
Sean McCarthyDivision of Gastroenterology, Ohio State University, Columbus, Ohio.
J Bayne SelbyDivision of Interventional Radiology, Medical University of South Carolina, Charleston, South Carolina.
Vikesh K SinghDivision of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Jason R TaylorDivision of Gastroenterology, Saint Louis University, St Louis, Missouri.
Field F WillinghamDivision of Digestive Diseases, Emory University, Atlanta, Georgia.
Rebecca L SpitzerDivision of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina.
Lydia D FosterDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
INTERCPT study group and the United States Cooperative for Outcomes Research in Endoscopy (USCORE)

Funding

Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
NIDDK NIH HHS P30 DK123704
6 · The paper itself

Abstract

Percutaneous transhepatic biliary drainage (PTBD) and endoscopic retrograde cholangiopancreatography (ERCP) are widely accepted but competing approaches for the management of malignant obstruction at the hilum of the liver. ERCP is favored in the United States on the basis of high success rates for non-hilar indications, the perceived safety and superior tissue sampling capability of ERCP relative to PTBD, and the avoidance of external drains that are undesirable to patients. A recent randomized controlled trial (RCT) comparing the 2 modalities in patients with resectable hilar cholangiocarcinoma was terminated prematurely because of higher mortality in the PTBD group.

Indexed as

Bile Duct NeoplasmsCholestasisBile Ducts, IntrahepaticCholangiopancreatography, Endoscopic RetrogradeDrainageEndosonographyHumans

Identifiers

PMID32454259
PMCPMC8776356

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.