Evidence map›Paper›PMID 32454115›Full record

ArticleThe Journal of pediatrics2020

Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study.

Mireille Guillot, Ting Guo, Steven Ufkes, Juliane Schneider, Anne Synnes, Vann Chau, Ruth E Grunau, Steven P Miller

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PubMed Publisher
In one paragraph

Article in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  14. Association of unplanned extubations and neurodevelopmental outcomes in very low birthweight infants.Journal of perinatology : official journal of the California Perinatal Association · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mireille GuillotDepartment of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada.
Ting GuoDepartment of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada.
Steven UfkesDepartment of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada.
Juliane SchneiderDepartment of Women-Mother-Child (Neonatology), University Hospital Center and University of Lausanne, Lausanne, Switzerland.
Anne SynnesBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Pediatrics (Neonatology), University of British Columbia and BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.
Vann ChauDepartment of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada.
Ruth E GrunauBC Children's Hospital Research Institute, Vancouver, British Columbia, Canada; Department of Pediatrics (Neonatology), University of British Columbia and BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.
Steven P MillerDepartment of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: steven.miller@sickkids.ca.
University of Toronto · CAUniversity of British Columbia · CAUniversity of Lausanne · CH

Funding

CIHR MOP-79262CIHR MOP-86489
6 · The paper itself

Abstract

objectivesTo determine, in children born preterm, the association of mechanical ventilation duration with brainstem development, white matter maturation, and neurodevelopmental outcomes at preschool age. STUDY

designThis prospective cohort study included 144 neonates born at <30 weeks of gestation (75 male, mean gestational age 27.1 weeks, SD 1.6) with regional brainstem volumes automatically segmented on magnetic resonance imaging at term-equivalent age (TEA). The white matter maturation was assessed by diffusion tensor imaging and tract-based spatial statistics. Neurodevelopmental outcomes were assessed at 4.5 years of age using the Movement Assessment Battery for Children, 2nd Edition, and the Wechsler Primary and Preschool Scale of Intelligence, 4th Edition, full-scale IQ. The association between the duration of mechanical ventilation and brainstem development was validated in an independent cohort of children born very preterm.

resultsEach additional day of mechanical ventilation predicted lower motor scores (0.5-point decrease in the Movement Assessment Battery for Children, 2nd Edition, score by day of mechanical ventilation, 95% CI -0.6 to -0.3, P < .0001). Prolonged exposure to mechanical ventilation was associated with smaller pons and medulla volumes at TEA in 2 independent cohorts, along with widespread abnormalities in white matter maturation. Pons and medulla volumes at TEA predicted motor outcomes at 4.5 years of age.

conclusionsIn neonates born very preterm, prolonged mechanical ventilation is associated with impaired brainstem development, abnormal white matter maturation, and lower motor scores at preschool age. Further research is needed to better understand the neural pathological mechanisms involved.

Indexed as

Brain StemChild DevelopmentChild, PreschoolCohort StudiesDiffusion Tensor ImagingFemaleHumansInfantInfant, NewbornInfant, PrematureInfant, Premature, DiseasesMagnetic Resonance ImagingMaleMotor ActivityNeurodevelopmental DisordersOrgan Sizebronchopulmonary dysplasiamotor developmentnewbornwhite matter

Identifiers

PMID32454115
OpenAlexW3026045632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.