Evidence map›Paper›PMID 32454092›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2020

Microvascular thrombosis: experimental and clinical implications.

Monica A Bray, Sarah E Sartain, Jahnavi Gollamudi, Rolando E Rumbaut

Open access · bronzeAbstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Guideline
  2. [Recent advances in application of venous superdrainage in perforator flaps].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  3. Lessons from a case report of thrombocytopenia-associated multiple organ failure secondary to Streptococcus suis infection: Diagnosis and treatment strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  4. Review
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  7. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
    Review
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Monica A BrayCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas; Baylor College of Medicine, Houston, Texas.
Sarah E SartainCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas; Baylor College of Medicine, Houston, Texas.
Jahnavi GollamudiCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas; Baylor College of Medicine, Houston, Texas.
Rolando E RumbautCenter for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, Texas; Baylor College of Medicine, Houston, Texas. Electronic address: rrumbaut@bcm.edu.
Baylor College of Medicine · USMichael E. DeBakey VA Medical Center · US

Funding

Hematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3M
Collaborative Research Training in Thrombosis and InflammationT32HL139425 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Miguel Angel Cruz, ROLANDO E RUMBAUT · 2018 to 2026
$2.4M
Platelets and microvascular thrombosis in inflammationI01BX002551 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI RUMBAUT, ROLANDO E · 2016 to 2025
–
BLRD VA I01 BX002551NHLBI NIH HHS T32 HL139425NIDDK NIH HHS T32 DK060445
6 · The paper itself

Abstract

A significant amount of clinical and research interest in thrombosis is focused on large vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however, thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. Further, microvascular thrombosis has recently been demonstrated in patients with COVID-19, and has been proposed to mediate the pathogenesis of organ injury in this disease. In many of these conditions, microvascular thrombosis is accompanied by inflammation, an association referred to as thromboinflammation. In this review, we discuss endogenous regulatory mechanisms that prevent thrombosis in the microcirculation, experimental approaches to induce microvascular thrombi, and clinical conditions associated with microvascular thrombosis. A greater understanding of the links between inflammation and thrombosis in the microcirculation is anticipated to provide optimal therapeutic targets for patients with diseases accompanied by microvascular thrombosis.

Indexed as

BetacoronavirusAnimalsCoronavirus InfectionsCOVID-19Endothelium, VascularHumansMicrocirculationMicrovesselsModels, CardiovascularPandemicsPneumonia, ViralSARS-CoV-2ThrombosisTranslational Research, Biomedical

Identifiers

PMID32454092
PMCPMC7245314
OpenAlexW3027101340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.