Evidence map›Paper›PMID 32454027›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2020

HIV-Resistant and HIV-Specific CAR-Modified CD4

Colby R Maldini, Kevin Gayout, Rachel S Leibman, Derrick L Dopkin, Joshua P Mills, Xiaochuan Shan, Joshua A Glover, James L Riley

Open access · hybridAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Article
  3. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Searching for a HIV-1 Cure.Theranostics · 2026
    Review
  8. Article
  9. Article
  10. Engineering of CD8mBio · 2025
    Article
  11. CD4Cell reports. Medicine · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. STK11 mutation affects tumor proliferation by impacting CD4Central-European journal of immunology · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Colby R MaldiniDepartment of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kevin GayoutDepartment of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Rachel S LeibmanDepartment of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Derrick L DopkinDeparment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joshua P MillsDepartment of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Xiaochuan ShanDeparment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Joshua A GloverDeparment of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
James L RileyDepartment of Microbiology, Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: rileyj@upenn.edu.
University of Pennsylvania · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DAVID S METZGER · 1999 to 2026
$78.6M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Modeling HIV CAR-T cell trafficking and persistence in Non-Human PrimatesU19AI149680 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RILEY, JAMES L. · 2020 to 2024
$13.2M
Sequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2015 to 2019
$12.0M
TRAINING IN HIV PATHOGENESIST32AI007632 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Frederic D Bushman, James L. Riley · 2000 to 2026
$10.6M
NIAID NIH HHS P30 AI045008NIAID NIH HHS T32 AI007632NIAID NIH HHS U19 AI117950NIAID NIH HHS U19 AI149680NIAID NIH HHS UM1 AI126620
6 · The paper itself

Abstract

HIV infection preferentially depletes HIV-specific CD4

Indexed as

AnimalsCD28 AntigensCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDisease Models, AnimalDisease ProgressionDrug Resistance, ViralHIVHIV-1HIV InfectionsHumansImmunotherapy, AdoptiveInducible T-Cell Co-Stimulator ProteinMiceProtein DomainsCD28 AntigensICOS protein, humanInducible T-Cell Co-Stimulator ProteinReceptors, Chimeric AntigenC34-CXCR4chimeric antigen receptorcostimulationIL-2IL-21in vivo model of HIVPD-1T cell helpTIGIT

Identifiers

PMID32454027
PMCPMC7335752
OpenAlexW3025602643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.