Evidence map›Paper›PMID 32453942›Full record

ArticleACS chemical biology2020

Genetic and Biochemical Reconstitution of Bromoform Biosynthesis in

Hem R Thapa, Zhenjian Lin, Dongqi Yi, Jennifer E Smith, Eric W Schmidt, Vinayak Agarwal

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Insights into the Red SeaweedPlants (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. The effects of temperature and COJournal of phycology · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits.medRxiv : the preprint server for health sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hem R ThapaSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0003-3864-6141
Zhenjian LinDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
Dongqi YiSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Jennifer E SmithCenter for Marine Biodiversity and Conservation, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States.
Eric W SchmidtDepartment of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.ORCID 0000-0001-5839-694X
Vinayak AgarwalSchool of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.ORCID 0000-0002-2517-589X
Georgia Institute of Technology · USUniversity of Utah · USScripps Institution of Oceanography · US

Funding

Symbiosis and Chemical Diversity GenerationR35GM122521 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2017 to 2021
$2.9M
Understanding natural production of polybrominated toxins and pollutantsR00ES026620 · NIEHS · GEORGIA INSTITUTE OF TECHNOLOGY · PI AGARWAL, VINAYAK · 2017 to 2019
$747k
Understanding natural production of polybrominated toxins and pollutantsK99ES026620 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AGARWAL, VINAYAK · 2016 to 2016
$86k
NIEHS NIH HHS K99 ES026620NIEHS NIH HHS R00 ES026620NIGMS NIH HHS R35 GM122521
6 · The paper itself

Abstract

Marine macroalgae, seaweeds, are exceptionally prolific producers of halogenated natural products. Biosynthesis of halogenated molecules in seaweeds is inextricably linked to reactive oxygen species (ROS) signaling as hydrogen peroxide serves as a substrate for haloperoxidase enzymes that participate in the construction these halogenated molecules. Here, using red macroalga

Indexed as

Fatty AcidsGas Chromatography-Mass SpectrometryGenome, PlantReactive Oxygen SpeciesSeaweedTrihalomethanesbromoformFatty AcidsReactive Oxygen SpeciesTrihalomethanes

Identifiers

PMID32453942
PMCPMC7306000
OpenAlexW3032699543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.