Evidence map›Paper›PMID 32453843›Full record

ArticleBlood advances2020

Methodology for the American Society of Hematology VTE guidelines: current best practice, innovations, and experiences.

Wojtek Wiercioch, Robby Nieuwlaat, Elie A Akl, Robert Kunkle, Kendall E Alexander, Adam Cuker, Anita Rajasekhar, Pablo Alonso-Coello, David R Anderson, Shannon M Bates and 16 more

Abstract read
In one paragraph

Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Guideline
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  10. Trial
  11. Article
  12. Article
  13. An international guideline training and certification programme.Bulletin of the World Health Organization · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. The value of the old and the new.Blood advances · 2023
    Article
  18. Observational
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Wojtek WierciochMichael G. DeGroote Cochrane Canada Centre.
Robby NieuwlaatMichael G. DeGroote Cochrane Canada Centre.
Elie A AklDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Robert KunkleAmerican Society of Hematology, Washington, DC.
Kendall E AlexanderAmerican Society of Hematology, Washington, DC.
Adam CukerDepartment of Medicine and.
Anita RajasekharDepartment of Medicine, University of Florida, Gainesville, FL.
Pablo Alonso-CoelloIberoamerican Cochrane Center, Biomedical Research Institute Sant Pau (IIB Sant Pau-Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública), Barcelona, Spain.
David R AndersonDepartment of Medicine, Dalhousie University, Halifax, NS, Canada.
Shannon M BatesDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Mary CushmanDepartment of Medicine and.
Philipp DahmUrology Section, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN.
Gordon GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Alfonso IorioDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Wendy LimDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Gary H LymanFred Hutchinson Cancer Research Center, Seattle, WA.
Saskia MiddeldorpDepartment of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Paul MonagleDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Reem A MustafaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Ignacio NeumannDepartment of Internal Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Thomas L OrtelDepartment of Medicine and.
Bram RochwergDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Nancy SantessoMichael G. DeGroote Cochrane Canada Centre.
Sara K VeselyDepartment of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK; and.
Daniel M WittDepartment of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, UT.
Holger J SchünemannMichael G. DeGroote Cochrane Canada Centre.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethods for the development of clinical guidelines have advanced dramatically over the past 2 decades to strive for trustworthiness, transparency, user-friendliness, and rigor. The American Society of Hematology (ASH) guidelines on venous thromboembolism (VTE) have followed these advances, together with application of methodological innovations.

objectiveIn this article, we describe methods and methodological innovations as a model to inform future guideline enterprises by ASH and others to achieve guideline standards. Methodological innovations introduced in the development of the guidelines aim to address current challenges in guideline development.

methodsWe followed ASH policy for guideline development, which is based on the Guideline International Network (GIN)-McMaster Guideline Development Checklist and current best practices. Central coordination, specialist working groups, and expert panels were established for the development of 10 VTE guidelines. Methodological guidance resources were developed to guide the process across guidelines panels. A methods advisory group guided the development and implementation of methodological innovations to address emerging challenges and needs.

resultsThe complete set of VTE guidelines will include >250 recommendations. Methodological innovations include the use of health-outcome descriptors, online voting with guideline development software, modeling of pathways for diagnostic questions, application of expert evidence, and a template manuscript for publication of ASH guidelines. These methods advance guideline development standards and have already informed other ASH guideline projects.

conclusionsThe development of the ASH VTE guidelines followed rigorous methods and introduced methodological innovations during guideline development, striving for the highest possible level of trustworthiness, transparency, user-friendliness, and rigor.

Indexed as

HematologyVenous ThromboembolismEvidence-Based MedicineHumansUnited States

Identifiers

PMID32453843
PMCPMC7252554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.