ArticleGenetics and molecular biology2020
Functional analysis of 4-coumarate: CoA ligase from Dryopteris fragrans in transgenic tobacco enhances lignin and flavonoids.
Article in Genetics and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- 4-Coumarate CoA Ligase Family in Soybean Responds toCurrent issues in molecular biology · 2025Article
- Article
- A dual transcriptome analysis reveals accession-specific resistance responses inFrontiers in plant science · 2025Article
- RNA-Seq Transcriptomics and iTRAQ Proteomics Analysis Reveal the Dwarfing Mechanism of Blue Fescue (Plants (Basel, Switzerland) · 2024Article
- Metabolite and Transcriptome Profiling Analysis Provides New Insights into the Distinctive Effects of Exogenous Melatonin on Flavonoids Biosynthesis inInternational journal of molecular sciences · 2024Article
- Physiological-Biochemical Characteristics and a Transcriptomic Profiling Analysis Reveal the Postharvest Wound Healing Mechanisms of Sweet Potatoes under Ascorbic Acid Treatment.Foods (Basel, Switzerland) · 2024Article
- Identification of key genes involved in lignin and flavonoid accumulation during Tilia tuan seed maturation.Plant cell reports · 2024Article
- Cloning and functional analysis of Gb4CL1 and Gb4CL2 from Ginkgo biloba.The plant genome · 2024Article
- Flavonoids are involved in salt tolerance through ROS scavenging in the halophyte Atriplex canescens.Plant cell reports · 2023Article
- Fusion gene 4CL-CCR promotes lignification in tobacco suspension cells.Plant cell reports · 2023Article
- Integrative Transcriptomic and Metabolomic Analysis Reveals the Molecular Mechanism of Red Maple (Metabolites · 2023Article
- A tracking work on how Sm4CL2 re-directed the biosynthesis of salvianolic acids and tanshinones in Salvia miltiorrhiza hairy roots.Plant cell reports · 2023Article
- Lignin and Its Pathway-Associated Phytoalexins Modulate Plant Defense against Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Overexpression of SugarcaneInternational journal of molecular sciences · 2022Article
- Combined Analysis of Pharmaceutical Active Ingredients and Transcriptomes ofFrontiers in plant science · 2022Article
- Phylogenetic Occurrence of the Phenylpropanoid Pathway and Lignin Biosynthesis in Plants.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
4-Coumaric acid: coenzyme A ligase (4CL) is a key enzyme in the phenylpropanoid metabolic pathway that regulates the biosynthesis of lignin and flavonoids. Therefore, the study of 4CL is important to explore the accumulation and regulation of metabolites. This study investigated the role that the 4CL2 gene from Dryopteris fragrans (Df4CL2) plays in the metabolite synthesis. Changes in gene expression, enzyme activity, and the content of lignin and flavonoids were measured in different tissues of tobacco as model plant that was successfully transferred with Df4CL2. Tobacco plants with Df4CL2 (transgenic tobacco, TT) were successfully obtained via the Agrobacterium-transformation method. This TT tended to be thicker and had an earlier flowering period than wild type tobacco (WT). The expression levels of Df4CL2 were higher in the stem, leaf, and root in TT compared to WT. In addition, compared to WT, TT had higher 4CL enzyme activity and higher lignin and flavonoids contents. This suggests that Df4CL2 is involved in the synthesis of lignin and flavonoids in D. fragrans. This research provides important evidence toward understanding the phenylpropanoid metabolic pathway in ferns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.