Evidence map›Paper›PMID 32452971›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Associations Between Widespread Pain and Sleep Quality in People With HIV.

Caroline A Sabin, Richard Harding, Nicki Doyle, Susan Redline, Davide de Francesco, Patrick W G Mallon, Frank A Post, Marta Boffito, Memory Sachikonye, Adam Geressu and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Caroline A SabinInstitute for Global Health, UCL, London, United Kingdom.
Richard HardingFlorence Nightingale Faculty, Cicely Saunders Institute, Kings College London, London, United Kingdom.
Nicki DoyleDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Susan RedlineDepartments of Medicine and Neurology, Harvard Medical School, Brigham and Women's Hospital.
Davide de FrancescoInstitute for Global Health, UCL, London, United Kingdom.
Patrick W G MallonHIV Molecular Research Group, School of Medicine, University College Dublin, Dublin, Ireland.
Frank A PostCaldecot Centre, King's College Hospital, London, United Kingdom.
Marta BoffitoSt. Stephen's Centre, Chelsea and Westminster Hospital, London, United Kingdom.
Memory SachikonyeUK Community Advisory Board (UK-CAB), London, United Kingdom.
Adam GeressuInstitute for Global Health, UCL, London, United Kingdom.
Alan WinstonImperial Clinical Trials Unit, Imperial College London, London, United Kingdom; and.
Ken M KunisakiMinneapolis Veterans Affairs Health Care System, University of Minnesota, Minnesota, MN.
Imperial College London · GBUniversity College London · GBBrigham and Women's Hospital · USChelsea and Westminster Hospital · GBKing's College Hospital · GBKing's College London · GBNational Institute for Health Research · GBUniversity College Dublin · IE

Funding

Sleep, Aging, and HIV Infection Cohort StudyR01HL131049 · NHLBI · UNIVERSITY OF MINNESOTA · PI KUNISAKI, KEN M., REDLINE, SUSAN S. · 2016 to 2019
$2.4M
Department of HealthNHLBI NIH HHS R01 HL131049Wellcome Trust
6 · The paper itself

Abstract

backgroundWe investigate the association of widespread pain with sleep quality among people with HIV and HIV-negative controls.

settingUK-based cohort.

methodsPain information was collected through a pain mannikin identifying affected body sites; pain was classified as widespread if pain was reported in ≥4 of 5 body regions and in ≥7 of 15 body sites, and as regional otherwise. Sleep was assessed a median of 3.2 years later through 7-night actigraphy and through self-reported assessments of sleep quality. Chi-squared tests, Kruskal-Wallis tests, and linear/logistic regression considered associations between pain extent and sleep quality.

resultsOf the 414 participants, 74 (17.9%) reported widespread and 189 (45.7%) regional pain. Although there were few clear associations between actigraphy outcomes and pain extent, those with widespread and regional pain consistently reported poorer sleep quality on all self-reported measures than those with no pain. Median (interquartile range) insomnia severity index and Patient-reported Outcomes Measurement Information System (PROMIS) for sleep disturbance and sleep-related impairment scores were 12 (7-16), 55.3 (48.0-58.9), and 57.2 (48.9-61.3), respectively, for those with widespread pain, 8 (4-13), 51.2 (45.5-58.3), and 50.3 (43.6-56.1) for those with regional pain, and 5 (2-9), 47.9 (42.9-54.3), and 45.5 (41.4-50.3) for those with no pain (all P values 0.0001). Associations remained strong after adjustment for HIV status and other confounders, and were reduced but remained significant, after adjustment for depressive symptoms.

conclusionsWidespread pain was not associated with objective measures of sleep but was strongly associated with self-reported assessments of sleep quality in people with HIV.

Indexed as

HIV-1PainActigraphyCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedSleep Wake Disorders

Identifiers

PMID32452971
PMCPMC9285009
OpenAlexW3031397352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.