ArticleeLife2020
Wnt/β-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Loss of U11/U12 spliceosome geneLife science alliance · 2026Article
- Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens.Molecular biology and evolution · 2026Article
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- LY294002 and LiCl Mitigate Neonatal ExPEC Meningitis Through Akt/GSK3β Signaling Modulation.Mediators of inflammation · 2026Article
- Article
- The Expression Profile of Wnt/β-Catenin Signalling Pathway Genes in Miscarriages.Balkan journal of medical genetics : BJMG · 2025Article
- Article
- An ancient apical patterning system sets the position of the forebrain in chordates.Science advances · 2025Article
- Anterior-Posterior Wnt Signaling Network Conservation between Indirect Developing Sea Urchin and Hemichordate Embryos.Integrative and comparative biology · 2024Article
- Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head.Nature communications · 2024Article
- The origin and evolution of Wnt signalling.Nature reviews. Genetics · 2024Review
- The Molecular Mechanism of Body Axis Induction in Lampreys May Differ from That in Amphibians.International journal of molecular sciences · 2024Article
- Gene networks and the evolution of olfactory organs, eyes, hair cells and motoneurons: a view encompassing lancelets, tunicates and vertebrates.Frontiers in cell and developmental biology · 2024Review
- Ancestral role of Pax6 in chordate brain regionalization.Frontiers in cell and developmental biology · 2024Article
- Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB.Nature communications · 2023Article
- The complete dorsal structure is formed from only the blastocoel roof of Xenopus blastula: insight into the gastrulation movement evolutionarily conserved among chordates.Development genes and evolution · 2023Article
- Origin, form and function of extraembryonic structures in teleost fishes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Evolution and loss of ß-catenin and TCF-dependent axis specification in insects.Current opinion in insect science · 2022Review
- The Organizer and Its Signaling in Embryonic Development.Journal of developmental biology · 2021Review
- Generation of pancreatic progenitors from human pluripotent stem cells by small molecules.Stem cell reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Deciphering the mechanisms of axis formation in amphioxus is a key step to understanding the evolution of chordate body plan. The current view is that Nodal signaling is the only factor promoting the dorsal axis specification in the amphioxus, whereas Wnt/β-catenin signaling plays no role in this process. Here, we re-examined the role of Wnt/βcatenin signaling in the dorsal/ventral patterning of amphioxus embryo. We demonstrated that the spatial activity of Wnt/β-catenin signaling is located in presumptive dorsal cells from cleavage to gastrula stage, and provided functional evidence that Wnt/β-catenin signaling is necessary for the specification of dorsal cell fate in a stage-dependent manner. Microinjection of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.