Evidence map›Paper›PMID 32452767›Full record

ArticleeLife2020

Nuclei determine the spatial origin of mitotic waves.

Felix E Nolet, Alexandra Vandervelde, Arno Vanderbeke, Liliana Piñeros, Jeremy B Chang, Lendert Gelens

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Mitotic Cdc42 waves encode PI(3,4)PScience advances · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Collective effects of cell cleavage dynamics.Frontiers in cell and developmental biology · 2024
    Review
  12. Robust trigger wave speed inbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Waves in Embryonic Development.Annual review of biophysics · 2022
    Review
  17. Specificity of Nuclear Size Scaling in Frog Erythrocytes.Frontiers in cell and developmental biology · 2022
    Article
  18. Article
  19. Cell cycle control during early embryogenesis.Development (Cambridge, England) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Felix E Nolet *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-9300-6302
Alexandra Vandervelde *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.
Arno Vanderbeke *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-7240-8377
Liliana Piñeros *Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-8872-9602
Jeremy B ChangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, United States.ORCID https://orcid.org/0000-0002-7381-6444
Lendert GelensLaboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-7290-9561
Systems Dynamics (United States) · USUniversity of California, San Francisco · US

Funding

KU Leuven Research Fund C14/18/084Research Foundation - Flanders GOA5317N
6 · The paper itself

Abstract

Traveling waves play an essential role in coordinating mitosis over large distances, but what determines the spatial origin of mitotic waves remains unclear. Here, we show that such waves initiate at pacemakers, regions that oscillate faster than their surroundings. In cell-free extracts of

Indexed as

MitosisModels, BiologicalAnimalsCell-Free SystemCell NucleusOvumXenopus laevisbiological oscillationsbiological wavescell cyclecomputational biologymitosispacemakersphysics of living systemsspatial coordinationsystems biologyxenopus

Identifiers

PMID32452767
PMCPMC7314552
OpenAlexW3029419358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.