Evidence map›Paper›PMID 32452667›Full record

ReviewBiochemistry2021

Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles.

Xiangzhao Ai, Shuyan Wang, Yaou Duan, Qiangzhe Zhang, Maggie S Chen, Weiwei Gao, Liangfang Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiangzhao AiDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Shuyan WangDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Yaou DuanDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Qiangzhe ZhangDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Maggie S ChenDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Weiwei GaoDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Liangfang ZhangDepartment of NanoEngineering, Chemical Engineering Program, and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-0637-0654

Funding

Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma MetastasisR01CA200574 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, SHULIN, ZHANG, LIANGFANG · 2016 to 2020
$1.8M
NCI NIH HHS R01 CA200574
6 · The paper itself

Abstract

There has been significant interest in developing cell membrane-coated nanoparticles due to their unique abilities of biomimicry and biointerfacing. As the technology progresses, it becomes clear that the application of these nanoparticles can be drastically broadened if additional functions beyond those derived from the natural cell membranes can be integrated. Herein, we summarize the most recent advances in the functionalization of cell membrane-coated nanoparticles. In particular, we focus on emerging methods, including (1) lipid insertion, (2) membrane hybridization, (3) metabolic engineering, and (4) genetic modification. These approaches contribute diverse functions in a nondisruptive fashion while preserving the natural function of the cell membranes. They also improve on the multifunctional and multitasking ability of cell membrane-coated nanoparticles, making them more adaptive to the complexity of biological systems. We hope that these approaches will serve as inspiration for more strategies and innovations to advance cell membrane coating technology.

Indexed as

Cell MembraneNanoparticlesAnimalsHumansMetabolic Engineering

Identifiers

PMID32452667
PMCPMC8507422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.