Evidence map›Paper›PMID 32452464›Full record

ArticleDevelopmental cognitive neuroscience2020

Neural correlates of cognitive variability in childhood autism and relation to heterogeneity in decision-making dynamics.

T Iuculano, A Padmanabhan, L Chen, J Nicholas, S Mitsven, C de Los Angeles, V Menon

Open access · goldAbstract read
In one paragraph

Article in Developmental cognitive neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
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  4. The Unique Roles of Executive Function in Co-Occurring Psychopathologies in Autism.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  5. Review
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  13. Neural Substrates of the Drift-Diffusion Model in Brain Disorders.Frontiers in computational neuroscience · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

T IuculanoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States; Centre National de la Recherche Scientifique & Université de Paris, La Sorbonne - UMR CNRS 8240, 75005, Paris, France. Electronic address: teresa.iuculano@u-paris.fr.
A PadmanabhanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States.
L ChenDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States.
J NicholasDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States.
S MitsvenDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States.
C de Los AngelesDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States.
V MenonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, 94305, United States; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, United States; Stanford Neuroscience Institute, Stanford University, Stanford, CA, 94305, United States. Electronic address: menon@stanford.edu.
Stanford University · USCentre National de la Recherche Scientifique · FRNeurosciences Institute · US

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
Mathematical Cognition in Autism: A Cognitive and Systems Neuroscience ApproachR01MH084164 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2011 to 2021
$6.7M
Integrative computational models of latent behavioral and neural constructs in children: a longitudinal developmental big-data approachR01MH121069 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2019 to 2023
$3.9M
NCATS NIH HHS UL1 TR003142NIMH NIH HHS R01 MH084164NIMH NIH HHS R01 MH121069
6 · The paper itself

Abstract

Heterogeneity in cognitive and academic abilities is a prominent feature of autism spectrum disorder (ASD), yet little is known about its underlying causes. Here we combine functional brain imaging during numerical problem-solving with hierarchical drift-diffusion models of behavior and standardized measures of numerical abilities to investigate neural mechanisms underlying cognitive variability in children with ASD, and their IQ-matched Typically Developing (TD) peers. Although the two groups showed similar levels of brain activation, the relation to individual abilities differed markedly in ventral temporal-occipital, parietal and prefrontal regions important for numerical cognition: children with ASD showed a positive correlation between functional brain activation and numerical abilities, whereas TD children showed the opposite pattern. Despite similar accuracy and response times, decision thresholds were significantly higher in the ASD group, suggesting greater evidence required for problem-solving. Critically, the relationship between individual abilities and engagement of prefrontal control systems anchored in the anterior insula was differentially moderated by decision threshold in subgroups of children with ASD. Our findings uncover novel cognitive and neural sources of variability in academically-relevant cognitive skills in ASD and suggest that multilevel measures and latent decision-making dynamics can aid in characterization of cognitive variability and heterogeneity in neurodevelopmental disorders.

Indexed as

Autism Spectrum DisorderBrainBrain MappingChildCognitionDecision MakingFemaleHumansMaleAutism Spectrum DisorderBrain imagingDecision-makingIndividual differencesNumerical problem-solving

Identifiers

PMID32452464
PMCPMC7160429
OpenAlexW2998857450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.