ArticleJournal of child psychology and psychiatry, and allied disciplines2021
Greater functional connectivity between sensory networks is related to symptom severity in toddlers with autism spectrum disorder.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Distinct features of EEG microstates in autism spectrum disorder revealed by meta-analysis: the contribution of individual age to heterogeneity across studies.Frontiers in psychiatry · 2025Pooled it
- Music therapy for autistic people.The Cochrane database of systematic reviews · 2022Pooled it
- Associations between chronic placental inflammation, fetal brain development and later autism traits.Brain, behavior, & immunity - health · 2026Article
- Youth Autistic Traits and Brain Activation States During Socioemotional Processing.The American journal of psychiatry · 2026Article
- Automating region selection with genetic algorithms for energy landscape analyses of brain dynamics.Patterns (New York, N.Y.) · 2026Article
- Alterations in Early Alpha-band Connectivity emerge in Infancy among children later diagnosed with Autism.medRxiv : the preprint server for health sciences · 2026Article
- Developmental Neurotoxicity of Alcohol from Neuronal Basis to Behavioural Outcomes: A Comprehensive Review.Neurology international · 2026Review
- Impact of prenatal exposure to airborne particulate matter on local functional connections in the cerebral cortex of neonates.NeuroImage · 2026Article
- A null findings study: graph theoretical analysis of the fetal functional connectome shows no relationships with future autistic traits.Neuroimage. Reports · 2026Article
- Multi-Site Classification of Autism Spectrum Disorder Using Spatially Constrained ICA on Resting-State fMRI Networks.Brain sciences · 2026Article
- Fetal functional connectivity prospectively associates with autistic traits in toddlerhood.NeuroImage. Clinical · 2026Article
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- Behavioral and neural interrelationships of sensory difficulties, intolerance of uncertainty, and anxiety in autistic children.Research in autism · 2025Article
- Functional connectivity between the visual and salience networks and autistic social features at school-age.Journal of neurodevelopmental disorders · 2025Article
- Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome.Science advances · 2025Article
- Dynamic functional adaptations during touch observation in autism: connectivity strength is linked to attitudes towards social touch and social responsiveness.Molecular autism · 2025Article
- Infraslow Dynamic Patterns in Human Cortical Networks Track a Spectrum of External to Internal Attention.Human brain mapping · 2025Article
- Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework.NeuroImage · 2024Article
- Identification of autism spectrum disorder using multiple functional connectivity-based graph convolutional network.Medical & biological engineering & computing · 2024Article
- Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis.European child & adolescent psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSymptoms of autism spectrum disorder (ASD) emerge in the first years of life. Yet, little is known about the organization and development of functional brain networks in ASD proximally to the symptom onset. Further, the relationship between brain network connectivity and emerging ASD symptoms and overall functioning in early childhood is not well understood.
methodsResting-state fMRI data were acquired during natural sleep from 24 young children with ASD and 23 typically developing (TD) children, aged 17-45 months. Intrinsic functional connectivity (iFC) within and between resting-state functional networks was derived with independent component analysis (ICA).
resultsIncreased iFC between visual and sensorimotor networks was found in young children with ASD compared to TD participants. Within the ASD group, the degree of overconnectivity between visual and sensorimotor networks was associated with greater autism symptoms. Age-related weakening of the visual-auditory between-network connectivity was observed in the ASD but not the TD group.
conclusionsTaken together, these results provide evidence for disrupted functional network maturation and differentiation, particularly involving visual and sensorimotor networks, during the first years of life in ASD. The observed pattern of greater visual-sensorimotor between-network connectivity associated with poorer clinical outcomes suggests that disruptions in multisensory brain circuitry may play a critical role for early development of behavioral skills and autism symptomatology in young children with ASD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.