ReviewJournal of physiology and biochemistry2020
A current view of molecular dissection in autophagy machinery.
Review in Journal of physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Naringenin attenuates slow-transit constipation by regulating the AMPK/mTOR/ULK1 signalling pathway:Frontiers in pharmacology · 2025Article
- The study of the mechanism of non-coding RNA regulation of programmed cell death in diabetic cardiomyopathy.Molecular and cellular biochemistry · 2024Review
- Methods to Assess Autophagic Activity in Dictyostelium.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Autophagy and hepatic lipid metabolism: mechanistic insight and therapeutic potential for MASLD.npj metabolic health and disease · 2024Review
- Drug discovery by targeting the protein-protein interactions involved in autophagy.Acta pharmaceutica Sinica. B · 2023Review
- Autophagy and Biomaterials: A Brief Overview of the Impact of Autophagy in Biomaterial Applications.Pharmaceutics · 2023Review
- The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach.Cellular and molecular neurobiology · 2023Review
- Expression levels of ROS and Atg proteins in the vitreous in rhegmatogenous retinal detachment.International journal of ophthalmology · 2023Article
- Emerging mechanistic insights of selective autophagy in hepatic diseases.Frontiers in pharmacology · 2023Review
- The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up.Progress in retinal and eye research · 2022Review
- Review
- Article
- Regulation of autophagy by non-coding RNAs in gastric cancer.Frontiers in oncology · 2022Review
- Evaluation of Autophagy Process in Differentiation of Human Induced Pluripotent Stem Cells toward Insulin Producing Cells.International journal of organ transplantation medicine · 2022Article
- Article
- Primary central nervous system lymphomas express immunohistochemical factors of autophagy.Scientific reports · 2021Article
- Article
- Mechanobiology of Autophagy: The Unexplored Side of Cancer.Frontiers in oncology · 2021Review
- Dengue Nonstructural Protein 1 Maintains Autophagy through Retarding Caspase-Mediated Cleavage of Beclin-1.International journal of molecular sciences · 2020Article
- Co-targeting of lysosome and mitophagy in cancer stem cells with chloroquine analogues and antibiotics.Journal of cellular and molecular medicine · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macroautophagy (hereafter called autophagy) is a highly conserved lysosomal pathway for catabolism of intracellular material in eukaryotic cells. Autophagy is also an essential homeostatic process through which intracellular components are recycled for reuse or energy production. The extremely regulated autophagy process begins with the formation of hallmarked double membrane bound organelles called autophagosomes which in turn fuse with lysosomes called autolysosomes and finally degrade the autophagic cargos. The multistages molecular machinery of autophagy is critically orchestrated by the action of a set of the autophagy proteins (Atg) and a supreme regulator, mTOR (mechanistic target of rapamycin). However, individual stages of autophagy are mechanistically complex and partially understood. In this review, the individual stages of autophagy are dissected, and the corresponding molecular regulation is discussed in view of current scientific knowledge of autophagy. This understanding of sequential events of autophagy machinery through this review may lead to great interest in the therapeutic potential for manipulating of autophagy in established diseases.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.