Evidence map›Paper›PMID 32451907›Full record

ArticleVirus genes2020

Molecular characterization of non-polio enteroviruses isolated from children with acute flaccid paralysis in IRAN, 2015-2018.

Ahmad Nejati, Seyed Mohsen Zahraei, Sussan Mahmoudi, Maryam Yousefi, Yaghoob Mollaei-Kandelous, Hamideh Tabatabaie, Najmeh Parhizgari, Parastoo Soheili, Soodeh Yousefipoor, Rakhshandeh Nategh and 1 more

Abstract read
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In one paragraph

Article in Virus genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ahmad NejatiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Seyed Mohsen ZahraeiVaccine Preventable Diseases Department, Center of Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran.
Sussan MahmoudiVaccine Preventable Diseases Department, Center of Communicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran.
Maryam YousefiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Yaghoob Mollaei-KandelousVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Hamideh TabatabaieVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Najmeh ParhizgariVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Parastoo SoheiliVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Soodeh YousefipoorVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Rakhshandeh NateghVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Shohreh ShahmahmoodiVirology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. shahmahmoodi@tums.ac.ir.ORCID http://orcid.org/0000-0003-2727-2201
Tehran University of Medical Sciences · IRMinistry of Health and Medical Education · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to polioviruses, non-polio enteroviruses (NPEVs) are frequently isolated from patients with acute flaccid paralysis (AFP) worldwide. In polio-free countries, there have been expectations that with disappearing wild poliovirus from the community, the rate of AFP would decrease, but the increasing number of AFP cases proved this notion to be wrong. There are speculations that NPEVs might be the cause of increasing AFP rate. The aim of this study was to investigate frequency, genetic diversity, circulation patterns of NPEVs isolated from AFP cases in Iran from 2015 to 2018. Fifty-three NPEVs were isolated from stool specimens of AFP cases during four years of AFP surveillance. Nested PCR and VP1 sequencing revealed 20 NPEV types in which Echovirus 3 (13.2%), Echovirus 6 (13.2%), Echovirus 7 (7.5%), Echovirus 13 (7.5%) and Echovirus 21 (7.5%) were the most frequent. Coxsackie B viruses were isolated for the first time in AFP cases in Iran. The phylogenetic analysis of Echovirus 3 and Echovirus 6 revealed that Iranian echovirus strains belonged to the same cluster, indicating these viruses have been circulating in Iran for a long time. Compared to global Echovirus 3 and Echovirus 6 references, Echovirus 3 and Echovirus 6 strains detected in this study were closely related to Indian and Malaysia strains, respectively. The results of this study demonstrated a wide variety of NPEV types in Iranian patients, some of which had not been reported in previous studies. Moreover, this study highlights the need for NPEV surveillance in AFP cases.

Indexed as

Central Nervous System Viral DiseasesEnterovirusEnterovirus InfectionsMyelitisNeuromuscular DiseasesChildFecesFemaleHumansIranMalePhylogenySeroepidemiologic StudiesSerogroupAcute flaccid paralysisMolecular typingNon-polio enterovirusesPhylogenetic tree

Identifiers

PMID32451907
OpenAlexW3030214856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.