Evidence map›Paper›PMID 32451823›Full record

ArticleJournal of thrombosis and thrombolysis2020

Systematic assessment of venous thromboembolism in COVID-19 patients receiving thromboprophylaxis: incidence and role of D-dimer as predictive factors.

Mathieu Artifoni, Gwenvael Danic, Giovanni Gautier, Pascal Gicquel, David Boutoille, François Raffi, Antoine Néel, Raphaël Lecomte

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05286268 (The Role of Ischemia Modified Albumin in Patients With COVID-19), which is not on this map. Cited by 146 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 26 pooled it
34.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05286268 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Role of Ischemia Modified Albumin in Patients With COVID-19

TypeobservationalSponsorLarissa University HospitalRan2022 to 2022Enrolled194ConditionsCOVID-19ArmsIschemia Modified Albumin
3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 26 syntheses or guidelines pooled it, 293 citations in OpenAlex.

  1. Anticoagulants for people hospitalised with COVID-19: a rapid reviewThe Cochrane database of systematic reviews · 2022
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  6. Risk factors for pulmonary embolism in patients with COVID-19: a systemic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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  16. High rates of pulmonary artery occlusions in COVID-19. A meta-analysis.European journal of clinical investigation · 2021
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  18. A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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  19. Prophylactic anticoagulants for people hospitalised with COVID-19.The Cochrane database of systematic reviews · 2020
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mathieu ArtifoniService de Médecine Interne, CHU de Nantes, 44093, Nantes, France.
Gwenvael DanicService de Médecine Interne, CHU de Nantes, 44093, Nantes, France.
Giovanni GautierService de Médecine Interne, CHU de Nantes, 44093, Nantes, France.
Pascal GicquelService de Médecine Polyvalente, CH de Châteaubriant, 44110, Châteaubriant, France.
David BoutoilleService de Maladies Infectieuses et Tropicales, CHU de Nantes, 44093, Nantes, France.
François RaffiService de Maladies Infectieuses et Tropicales, CHU de Nantes, 44093, Nantes, France.
Antoine NéelService de Médecine Interne, CHU de Nantes, 44093, Nantes, France.
Raphaël LecomteService de Maladies Infectieuses et Tropicales, CHU de Nantes, 44093, Nantes, France. raphael.lecomte@chu-nantes.fr.ORCID http://orcid.org/0000-0003-2144-9221
Centre Hospitalier Universitaire de Nantes · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coagulopathy in COVID-19 is a burning issue and strategies to prevent thromboembolic events are debated and highly heterogeneous. The objective was to determine incidence and risk factors of venous thromboembolism (VTE) in COVID-19 inpatients receiving thromboprophylaxis. In this retrospective French cohort study, patients hospitalized in medical wards non-ICU with confirmed COVID-19 and adequate thromboprophylaxis were included. A systematic low limb venous duplex ultrasonography was performed at hospital discharge or earlier if deep venous thrombosis (DVT) was clinically suspected. Chest angio-CT scan was performed when pulmonary embolism (PE) was suspected. Of 71 patients, 16 developed VTE (22.5%) and 7 PE (10%) despite adequate thromboprophylaxis. D-dimers at baseline were significantly higher in patients with DVT (p < 0.001). Demographics, comorbidities, disease manifestations, severity score, and other biological parameters, including inflammatory markers, were similar in patients with and without VTE. The negative predictive value of a baseline D-dimer level < 1.0 µg/ml was 90% for VTE and 98% for PE. The positive predictive value for VTE was 44% and 67% for D-dimer level ≥ 1.0 µg/ml and ≥ 3 µg/ml, respectively. The association between D-dimer level and VTE risk increased by taking into account the latest available D-dimer level prior to venous duplex ultrasonography for the patients with monitoring of D-dimer. Despite thromboprophylaxis, the risk of VTE is high in COVID-19 non-ICU inpatients. Increased D-dimer concentrations of more than 1.0 μg/ml predict the risk of venous thromboembolism. D-dimer level-guided aggressive thromboprophylaxis regimens using higher doses of heparin should be evaluated in prospective studies.

Indexed as

AgedAnticoagulantsCoronavirus InfectionsCOVID-19EnoxaparinFemaleFibrin Fibrinogen Degradation ProductsFranceHumansIncidenceMaleMiddle AgedPandemicsPneumonia, ViralRetrospective StudiesVenous ThromboembolismAnticoagulantsEnoxaparinFibrin Fibrinogen Degradation Productsfibrin fragment DCOVID-19D-dimerPulmonary embolismVenous thromboembolism

Identifiers

PMID32451823
PMCPMC7246965
OpenAlexW3029192481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.