Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2020
Long-term outcomes following intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 5-year treatment arm results from a prospective randomized double-blind sham-controlled multi-center study.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05660512 (A Prospective Single Arm Cohort Study of Intraosseous Basivertebral Nerve Ablation), which is not on this map. Cited by 62 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Single Arm Cohort Study of Intraosseous Basivertebral Nerve Ablation
Who cites it
62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Radiofrequency ablation of basivertebral and sinuvertebral nerves for chronic discogenic low back pain: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- The effectiveness of intradiscal corticosteroid injection for the treatment of chronic discovertebral low back pain: a systematic review.Pain medicine (Malden, Mass.) · 2024Pooled it
- The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebrogenic Low Back Pain: An Updated Systematic Review with Single-Arm Meta-analysis.Pain medicine (Malden, Mass.) · 2022Pooled it
- Adverse events associated with basivertebral nerve radiofrequency ablation: A comprehensive analysis from the MAUDE database.Interventional pain medicine · 2026Article
- Sustained pain relief across modic subtypes following basivertebral nerve ablation: A real-world study.Interventional pain medicine · 2026Article
- Durable pain relief following basivertebral nerve ablation in patients with prior lumbar decompression: A retrospective case series.Interventional pain medicine · 2026Article
- The Sinuvertebral Nerve and Basivertebral Nerve: Analyzing the Central Role of the Vertebral-Disc Unit in Chronic Low Back Pain.Current pain and headache reports · 2026Review
- L5-S1 basivertebral nerve ablation for chronic vertebrogenic low back pain following lumbar fusion: a case report.Journal of spine surgery (Hong Kong) · 2026Article
- The utility of SPECT-CT in identifying vertebral endplate changes for basivertebral nerve ablation: A retrospective study with MRI comparison.Interventional pain medicine · 2026Article
- Early pain-response trajectories after basivertebral nerve ablation and their relationship to 12-month clinical outcomes.Interventional pain medicine · 2026Article
- Basivertebral nerve ablation provides comparable early pain relief in patients with psychiatric conditions: A real-world study.Interventional pain medicine · 2026Article
- The effectiveness of basivertebral nerve radiofrequency ablation for the treatment of vertebrogenic low back pain: 1-year results of a prospective real-world cohort study.Pain medicine (Malden, Mass.) · 2026Article
- Modic changes and their role in vertebrogenic back pain: a literature review.Skeletal radiology · 2026Review
- From Modic changes to the disc-endplate-bone marrow complex: imaging stratification, immune remodeling, and translational implications in intervertebral disc degeneration.Frontiers in immunology · 2026Review
- Rates of lumbar vertebral body compression fracture after basivertebral nerve ablation: A retrospective study utilizing a large national database.Interventional pain medicine · 2025Article
- [Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach : German version].Schmerz (Berlin, Germany) · 2025Article
- Timing and trajectory of pain and functional outcomes after basivertebral nerve ablation: a prospective cohort study.Interventional pain medicine · 2025Article
- Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review.North American Spine Society journal · 2025Article
- Synergistic Effects of Basivertebral Nerve Ablation Plus Schroth Therapy for Adult Scoliosis: A Multicenter Propensity-Matched Cohort Study.Pain and therapy · 2025Article
- Intraosseous Basivertebral Nerve Ablation for Spinal Pain: A Perspective Review.Annals of rehabilitation medicine · 2025Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDamaged or degenerated vertebral endplates are a significant cause of vertebrogenic chronic low back pain (CLBP). Modic changes are one objective MRI biomarker for these patients. Prior data from the treatment arm of a sham-controlled, RCT showed maintenance of clinical improvements at 2 years following ablation of the basivertebral nerve (BVN). This study reports 5-year clinical outcomes.
methodsIn total, 117 US patients were treated successfully with BVN ablation. Patient-reported outcomes of ODI, VAS, postablation treatments, and patient satisfaction were collected at a minimum of 5-years following BVN ablation. Primary outcome was mean change in ODI. Comparisons between the postablation and baseline values were made using an analysis of covariance with alpha 0.05.
resultsOf the 117 US treated patients 100 (85%) were available for review with a mean follow-up of 6.4 years (5.4-7.8 years). Mean ODI score improved from 42.81 to 16.86 at 5-year follow-up, a reduction of 25.95 points (p < 0.001). Mean reduction in VAS pain score was 4.38 points (baseline of 6.74, p < 0.001). In total, 66% of patients reported a > 50% reduction in pain, 47% reported a > 75% reduction in pain, and 34% of patients reported complete pain resolution. Composite responder rate using thresholds of ≥ 15-point ODI and ≥ 2-point VAS for function and pain at 5 years was 75%.
conclusionCLBP patients treated with BVN ablation exhibit sustained clinical improvements in function and pain with high responder rates at a mean of 6.4 years following treatment. BVN ablation is a durable, minimally invasive treatment for vertebrogenic CLBP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.